{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sebastian M"],"funding":["Intramural NIH HHS"],"pagination":["144-55"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4685018"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["196(1)"],"pubmed_abstract":["A subpopulation (60-70%) of Foxp3(+) regulatory T cells (Tregs) in both mouse and man expresses the transcription factor Helios, but its role in Treg function is still unknown. We generated Treg-specific Helios-deficient mice to examine the function of Helios in Tregs. We show that the selective deletion of Helios in Tregs leads to slow, progressive systemic immune activation, hypergammaglobulinemia, and enhanced germinal center formation in the absence of organ-specific autoimmunity. Helios-deficient Treg suppressor function was normal in vitro, as well as in an in vivo inflammatory bowel disease model. However, Helios-deficient Tregs failed to control the expansion of pathogenic T cells derived from scurfy mice, failed to mediate T follicular regulatory cell function, and failed to contr"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Helios Controls a Limited Subset of Regulatory T Cell Functions."],"pmcid":["PMC4685018"],"funding_grant_id":["Z01 AI000959-02"],"pubmed_authors":["Thornton AM","Shevach EM","Lopez-Ocasio M","Sebastian M","Metidji A","Rieder SA"],"additional_accession":[]},"is_claimable":false,"name":"Helios Controls a Limited Subset of Regulatory T Cell Functions.","description":"A subpopulation (60-70%) of Foxp3(+) regulatory T cells (Tregs) in both mouse and man expresses the transcription factor Helios, but its role in Treg function is still unknown. We generated Treg-specific Helios-deficient mice to examine the function of Helios in Tregs. We show that the selective deletion of Helios in Tregs leads to slow, progressive systemic immune activation, hypergammaglobulinemia, and enhanced germinal center formation in the absence of organ-specific autoimmunity. Helios-deficient Treg suppressor function was normal in vitro, as well as in an in vivo inflammatory bowel disease model. However, Helios-deficient Tregs failed to control the expansion of pathogenic T cells derived from scurfy mice, failed to mediate T follicular regulatory cell function, and failed to contr","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-22T11:37:40.741Z","creation":"2019-03-27T02:05:29Z"},"accession":"S-EPMC4685018","cross_references":{"pubmed":["26582951"],"doi":["10.4049/jimmunol.1501704"]}}