{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Varmeh S"],"funding":["NIDDK NIH HHS","NCI NIH HHS"],"pagination":["152-62"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4688239"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["159(1)"],"pubmed_abstract":["<h4>Background</h4>Investigating BRAF((V600E)) inhibitors (BRAFi) as a strategy to treat patients with aggressive thyroid tumors harboring the BRAF((V600E)) mutant currently is in progress, and drug resistance is expected to pose a challenge. MicroRNAs (miRNAs) are involved in development of resistance to a variety of drugs in different malignancies.<h4>Methods</h4>miRNA expression profiles in the human anaplastic thyroid cancer cell line (8505c) were compared with its PLX4720-resistant counterpart (8505c-R) by the use of Illumina deep sequencing. We conducted a functional annotation and pathway analysis of the putative and experimentally validated target genes of the significantly altered miRNAs.<h4>Results</h4>We identified 61 known and 2 novel miRNAs whose expression was altered greatly"],"journal":["Surgery"],"pubmed_title":["Genome-wide analysis of differentially expressed miRNA in PLX4720-resistant and parental human thyroid cancer cell lines."],"pmcid":["PMC4688239"],"funding_grant_id":["P30 DK040561","R01 CA149738","1R01CA149738-01A1"],"pubmed_authors":["Varmeh S","Sadreyev RI","Brauner E","Holm T","Vanden Borre P","Wang Y","Parangi S","Gunda V"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide analysis of differentially expressed miRNA in PLX4720-resistant and parental human thyroid cancer cell lines.","description":"<h4>Background</h4>Investigating BRAF((V600E)) inhibitors (BRAFi) as a strategy to treat patients with aggressive thyroid tumors harboring the BRAF((V600E)) mutant currently is in progress, and drug resistance is expected to pose a challenge. MicroRNAs (miRNAs) are involved in development of resistance to a variety of drugs in different malignancies.<h4>Methods</h4>miRNA expression profiles in the human anaplastic thyroid cancer cell line (8505c) were compared with its PLX4720-resistant counterpart (8505c-R) by the use of Illumina deep sequencing. We conducted a functional annotation and pathway analysis of the putative and experimentally validated target genes of the significantly altered miRNAs.<h4>Results</h4>We identified 61 known and 2 novel miRNAs whose expression was altered greatly","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-03T22:41:26.081Z","creation":"2019-03-27T02:05:40Z"},"accession":"S-EPMC4688239","cross_references":{"pubmed":["26456124"],"doi":["10.1016/j.surg.2015.06.046"]}}