{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(12)"],"submitter":["Wiegand SB"],"pubmed_abstract":["<h4>Background</h4>SNPs near the interferon lambda (IFNL) 3 gene are predictors for sustained virological response (SVR) in patients with chronic hepatitis C genotype (GT) 1. In addition, a dinucleotide frame shift in ss469415590 was described, which generates IFNL4. In this study, we compared the role of IFNL4 variants with IFNL3-(rs12979860) and IFNL3-(rs8099917) on response to pegylated (PEG)-IFN and Ribavirin (RBV) in patients with chronic hepatitis C GT2/3.<h4>Methods</h4>We recruited 1006 patients with chronic hepatitis C and GT2/3 in a large German registry. A treatment with PEG-IFN and Ribavirin was started by 959 patients. We performed genotyping of IFNL3 (rs12979860, n = 726; rs8099917, n = 687) and of IFNL4 (ss469415590; n = 631).<h4>Results</h4>Both preferable IFNL3 genotypes w"],"journal":["PloS one"],"pagination":["e0145622"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4689517"],"repository":["biostudies-literature"],"pubmed_title":["Performance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting."],"pmcid":["PMC4689517"],"pubmed_authors":["Naumann U","Lueth S","Heidrich B","Grigorian N","Petersen J","Link R","Boker KH","Manns MP","Wiegand SB","Sarrazin C","Rogalska-Taranta M","Malfertheiner P","Wedemeyer H","Cornberg M","John C","Susser S"],"additional_accession":[]},"is_claimable":false,"name":"Performance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting.","description":"<h4>Background</h4>SNPs near the interferon lambda (IFNL) 3 gene are predictors for sustained virological response (SVR) in patients with chronic hepatitis C genotype (GT) 1. In addition, a dinucleotide frame shift in ss469415590 was described, which generates IFNL4. In this study, we compared the role of IFNL4 variants with IFNL3-(rs12979860) and IFNL3-(rs8099917) on response to pegylated (PEG)-IFN and Ribavirin (RBV) in patients with chronic hepatitis C GT2/3.<h4>Methods</h4>We recruited 1006 patients with chronic hepatitis C and GT2/3 in a large German registry. A treatment with PEG-IFN and Ribavirin was started by 959 patients. We performed genotyping of IFNL3 (rs12979860, n = 726; rs8099917, n = 687) and of IFNL4 (ss469415590; n = 631).<h4>Results</h4>Both preferable IFNL3 genotypes w","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-05-05T19:58:56.221Z","creation":"2019-03-26T22:56:42Z"},"accession":"S-EPMC4689517","cross_references":{"pubmed":["26699619"],"doi":["10.1371/journal.pone.0145622"]}}