biostudies-literatureUnknown10(12)Wiegand SB<h4>Background</h4>SNPs near the interferon lambda (IFNL) 3 gene are predictors for sustained virological response (SVR) in patients with chronic hepatitis C genotype (GT) 1. In addition, a dinucleotide frame shift in ss469415590 was described, which generates IFNL4. In this study, we compared the role of IFNL4 variants with IFNL3-(rs12979860) and IFNL3-(rs8099917) on response to pegylated (PEG)-IFN and Ribavirin (RBV) in patients with chronic hepatitis C GT2/3.<h4>Methods</h4>We recruited 1006 patients with chronic hepatitis C and GT2/3 in a large German registry. A treatment with PEG-IFN and Ribavirin was started by 959 patients. We performed genotyping of IFNL3 (rs12979860, n = 726; rs8099917, n = 687) and of IFNL4 (ss469415590; n = 631).<h4>Results</h4>Both preferable IFNL3 genotypes wPloS onee0145622https://www.ebi.ac.uk/biostudies/studies/S-EPMC4689517biostudies-literaturePerformance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting.PMC4689517Naumann ULueth SHeidrich BGrigorian NPetersen JLink RBoker KHManns MPWiegand SBSarrazin CRogalska-Taranta MMalfertheiner PWedemeyer HCornberg MJohn CSusser SfalsePerformance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting.<h4>Background</h4>SNPs near the interferon lambda (IFNL) 3 gene are predictors for sustained virological response (SVR) in patients with chronic hepatitis C genotype (GT) 1. In addition, a dinucleotide frame shift in ss469415590 was described, which generates IFNL4. In this study, we compared the role of IFNL4 variants with IFNL3-(rs12979860) and IFNL3-(rs8099917) on response to pegylated (PEG)-IFN and Ribavirin (RBV) in patients with chronic hepatitis C GT2/3.<h4>Methods</h4>We recruited 1006 patients with chronic hepatitis C and GT2/3 in a large German registry. A treatment with PEG-IFN and Ribavirin was started by 959 patients. We performed genotyping of IFNL3 (rs12979860, n = 726; rs8099917, n = 687) and of IFNL4 (ss469415590; n = 631).<h4>Results</h4>Both preferable IFNL3 genotypes w2015-01-01T00:00:00Z20152026-05-05T19:58:56.221Z2019-03-26T22:56:42ZS-EPMC46895172669961910.1371/journal.pone.0145622