{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Goldufsky J"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","NINR NIH HHS"],"pagination":["557-64"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4690211"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(4)"],"pubmed_abstract":["Diabetic foot ulcers are responsible for more hospitalizations than any other complication of diabetes. Bacterial infection is recognized as an important factor associated with impaired healing in diabetic ulcers. Pseudomonas aeruginosa is the most frequently detected Gram-negative pathogen in diabetic ulcers. P. aeruginosa infection has been shown to impair healing in diabetic wounds in a manner that correlates with its ability to form biofilm. While the majority of infections in diabetic ulcers are biofilm associated, 33% of infections are nonbiofilm in nature. P. aeruginosa is the most prevalent Gram-negative pathogen in all diabetic wound types, which suggests that the deleterious impact of P. aeruginosa on healing in diabetic wounds goes beyond its ability to form biofilm and likely i"],"journal":["Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society"],"pubmed_title":["Pseudomonas aeruginosa uses T3SS to inhibit diabetic wound healing."],"pmcid":["PMC4690211"],"funding_grant_id":["R21NR013876-0","R21 AI110685","R21 AI110685-01","R21 NR013876","R56 DK107713"],"pubmed_authors":["Goldufsky J","Jayaraman V","DiPietro LA","Chen L","Wood SJ","Shafikhani SH","Majdobeh O","Zhang C","Qin S"],"additional_accession":[]},"is_claimable":false,"name":"Pseudomonas aeruginosa uses T3SS to inhibit diabetic wound healing.","description":"Diabetic foot ulcers are responsible for more hospitalizations than any other complication of diabetes. Bacterial infection is recognized as an important factor associated with impaired healing in diabetic ulcers. Pseudomonas aeruginosa is the most frequently detected Gram-negative pathogen in diabetic ulcers. P. aeruginosa infection has been shown to impair healing in diabetic wounds in a manner that correlates with its ability to form biofilm. While the majority of infections in diabetic ulcers are biofilm associated, 33% of infections are nonbiofilm in nature. P. aeruginosa is the most prevalent Gram-negative pathogen in all diabetic wound types, which suggests that the deleterious impact of P. aeruginosa on healing in diabetic wounds goes beyond its ability to form biofilm and likely i","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul-Aug","modification":"2025-04-04T22:29:05.019Z","creation":"2019-03-27T02:05:45Z"},"accession":"S-EPMC4690211","cross_references":{"pubmed":["25912785"],"doi":["10.1111/wrr.12310"]}}