{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(28)"],"submitter":["Liu X"],"pubmed_abstract":["Growing evidence indicates that microRNA (miRNA) plays a vital role in progression and metastasis of gastric cancer (GC). However, the underlying mechanism of miRNA-mediated metastasis has not been fully understood. Recently, miRNA-940 (miR-940) was found to be overexpressed in GC, which correlated with malignant progression and poor survival. Mechanistically, we found that miR-940 promoted GC cell migration, invasion, and metastasis in vivo by directly and functionally repressing the expression of Zinc Finger Transcription Factor 24 (ZNF24). Importantly, upregulation of ZNF24 could re-inhibit miR-940-induced migration and invasion. Hence, we demonstrated the oncogenic role of miR-940 in GC, finding that miR-940 promoted GC progression by directly downregulating ZNF24 expression, and targeting miR-940 could serve as a novel strategy for future GC therapy."],"journal":["Oncotarget"],"pagination":["25418-28"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4694841"],"repository":["biostudies-literature"],"pubmed_title":["MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer."],"pmcid":["PMC4694841"],"pubmed_authors":["Liu X","Wu Z","Sun M","Li J","Zhang Z","Gan L","Ge X","Zhang X","Chang J","Tang W"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer.","description":"Growing evidence indicates that microRNA (miRNA) plays a vital role in progression and metastasis of gastric cancer (GC). However, the underlying mechanism of miRNA-mediated metastasis has not been fully understood. Recently, miRNA-940 (miR-940) was found to be overexpressed in GC, which correlated with malignant progression and poor survival. Mechanistically, we found that miR-940 promoted GC cell migration, invasion, and metastasis in vivo by directly and functionally repressing the expression of Zinc Finger Transcription Factor 24 (ZNF24). Importantly, upregulation of ZNF24 could re-inhibit miR-940-induced migration and invasion. Hence, we demonstrated the oncogenic role of miR-940 in GC, finding that miR-940 promoted GC progression by directly downregulating ZNF24 expression, and targeting miR-940 could serve as a novel strategy for future GC therapy.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2025-04-04T03:42:13.863Z","creation":"2019-03-27T02:05:56Z"},"accession":"S-EPMC4694841","cross_references":{"pubmed":["26317898"],"doi":["10.18632/oncotarget.4456"]}}