biostudies-literatureUnknown6(28)Liu XGrowing evidence indicates that microRNA (miRNA) plays a vital role in progression and metastasis of gastric cancer (GC). However, the underlying mechanism of miRNA-mediated metastasis has not been fully understood. Recently, miRNA-940 (miR-940) was found to be overexpressed in GC, which correlated with malignant progression and poor survival. Mechanistically, we found that miR-940 promoted GC cell migration, invasion, and metastasis in vivo by directly and functionally repressing the expression of Zinc Finger Transcription Factor 24 (ZNF24). Importantly, upregulation of ZNF24 could re-inhibit miR-940-induced migration and invasion. Hence, we demonstrated the oncogenic role of miR-940 in GC, finding that miR-940 promoted GC progression by directly downregulating ZNF24 expression, and targeting miR-940 could serve as a novel strategy for future GC therapy.Oncotarget25418-28https://www.ebi.ac.uk/biostudies/studies/S-EPMC4694841biostudies-literatureMicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer.PMC4694841Liu XWu ZSun MLi JZhang ZGan LGe XZhang XChang JTang WfalseMicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer.Growing evidence indicates that microRNA (miRNA) plays a vital role in progression and metastasis of gastric cancer (GC). However, the underlying mechanism of miRNA-mediated metastasis has not been fully understood. Recently, miRNA-940 (miR-940) was found to be overexpressed in GC, which correlated with malignant progression and poor survival. Mechanistically, we found that miR-940 promoted GC cell migration, invasion, and metastasis in vivo by directly and functionally repressing the expression of Zinc Finger Transcription Factor 24 (ZNF24). Importantly, upregulation of ZNF24 could re-inhibit miR-940-induced migration and invasion. Hence, we demonstrated the oncogenic role of miR-940 in GC, finding that miR-940 promoted GC progression by directly downregulating ZNF24 expression, and targeting miR-940 could serve as a novel strategy for future GC therapy.2015-01-01T00:00:00Z2015 Sep2025-04-04T03:42:13.863Z2019-03-27T02:05:56ZS-EPMC46948412631789810.18632/oncotarget.4456