{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(28)"],"submitter":["Kumazaki M"],"pubmed_abstract":["Tumor necrosis-factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF-superfamily that selectively induces apoptosis through death receptors (DRs) 4 and/or 5 in cancer cells. These receptors are expressed on the cancer cell surface, without affecting normal cells. Unfortunately, many clinical studies have shown that cancer cells acquire TRAIL-resistance and finally avoid TRAIL-induced apoptosis. The detailed mechanisms of this resistance are not well understood. In the current study, we established a TRAIL-resistant human colon cancer DLD-1 cell line to clarify the mechanisms of TRAIL-resistance and developed agents to cancel its machinery. Also, we found that cancer stem-like cells from breast epithelial proliferating MCF10A cells were also sensitive to TRAIL-induce"],"journal":["Oncotarget"],"pagination":["25828-42"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4694869"],"repository":["biostudies-literature"],"pubmed_title":["Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by α-mangostin, a xanthone derivative."],"pmcid":["PMC4694869"],"pubmed_authors":["Shinohara H","Ryo A","Taniguchi K","Akao Y","Nishi M","Kumazaki M","Ueda H"],"additional_accession":[]},"is_claimable":false,"name":"Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by α-mangostin, a xanthone derivative.","description":"Tumor necrosis-factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF-superfamily that selectively induces apoptosis through death receptors (DRs) 4 and/or 5 in cancer cells. These receptors are expressed on the cancer cell surface, without affecting normal cells. Unfortunately, many clinical studies have shown that cancer cells acquire TRAIL-resistance and finally avoid TRAIL-induced apoptosis. The detailed mechanisms of this resistance are not well understood. In the current study, we established a TRAIL-resistant human colon cancer DLD-1 cell line to clarify the mechanisms of TRAIL-resistance and developed agents to cancel its machinery. Also, we found that cancer stem-like cells from breast epithelial proliferating MCF10A cells were also sensitive to TRAIL-induce","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2025-04-04T03:42:20.689Z","creation":"2019-03-27T02:05:56Z"},"accession":"S-EPMC4694869","cross_references":{"pubmed":["26304927"],"doi":["10.18632/oncotarget.4558"]}}