{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Borrelli A"],"pubmed_abstract":["A 24-amino acid leader peptide of a new human recombinant manganese superoxide dismutase can enter cells and carry molecules. Here, we demonstrated that six of the 24 amino acids penetrate cells through a particular gate represented by a specific amino acid sequence of the oestrogen receptor (ER). We analysed the internalization of the synthetic hexapeptide and the cytotoxic activity of the hexapeptide conjugated to cisplatin on a cell line panel. In most cell lines, the hexapeptide delivered an amount of cisplatin that was 2 to 8 times greater than that released by cisplatin when the drug was used alone. This increased delivery increases the therapeutic index of cisplatin and reduces side effects caused by a high dosage or long-term treatment times. We may consider this hexapeptide a new "],"journal":["Scientific reports"],"pagination":["18691"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4698655"],"repository":["biostudies-literature"],"pubmed_title":["A new hexapeptide from the leader peptide of rMnSOD enters cells through the oestrogen receptor to deliver therapeutic molecules."],"pmcid":["PMC4698655"],"pubmed_authors":["Birolo L","Pica A","Mancini A","Tuccillo FM","Capasso C","Bonelli P","De Luca V","Ruggiero MG","Pucci P","Mancini R","Pollio ML","Sanseverino M","Borrelli A","Schiattarella A","Carpentieri A","Gori E","Rommelaere J"],"additional_accession":[]},"is_claimable":false,"name":"A new hexapeptide from the leader peptide of rMnSOD enters cells through the oestrogen receptor to deliver therapeutic molecules.","description":"A 24-amino acid leader peptide of a new human recombinant manganese superoxide dismutase can enter cells and carry molecules. Here, we demonstrated that six of the 24 amino acids penetrate cells through a particular gate represented by a specific amino acid sequence of the oestrogen receptor (ER). We analysed the internalization of the synthetic hexapeptide and the cytotoxic activity of the hexapeptide conjugated to cisplatin on a cell line panel. In most cell lines, the hexapeptide delivered an amount of cisplatin that was 2 to 8 times greater than that released by cisplatin when the drug was used alone. This increased delivery increases the therapeutic index of cisplatin and reduces side effects caused by a high dosage or long-term treatment times. We may consider this hexapeptide a new ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-22T11:35:18.026Z","creation":"2019-03-27T02:06:08Z"},"accession":"S-EPMC4698655","cross_references":{"pubmed":["26725847"],"doi":["10.1038/srep18691"]}}