biostudies-literatureUyoga SEuropean Community&apos;s Seventh Framework ProgrammeMedical Research CouncilWellcome Truste437-44https://www.ebi.ac.uk/biostudies/studies/S-EPMC4703047biostudies-literatureUnknown2(10)<h4>Background</h4>The global prevalence of X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is thought to be a result of selection by malaria, but epidemiological studies have yielded confusing results. We investigated the relationships between G6PD deficiency and both malaria and non-malarial illnesses among children in Kenya.<h4>Methods</h4>We did this study in Kilifi County, Kenya, where the G6PD c.202T allele is the only significant cause of G6PD deficiency. We tested the associations between G6PD deficiency and severe and complicated Plasmodium falciparum malaria through a case-control study of 2220 case and 3940 control children. Cases were children aged younger than 14 years, who visited the high dependency ward of Kilifi County Hospital with severe malaria between MarcThe Lancet. HaematologyGlucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study.PMC4703047091758MR/M006212/1FP7/2007-2013MC_UP_A900_1118G19/9077383090770084535G0600718090532092654Uyoga SPoudiougou BDembele AAnyorigiya TBah AAntwi STaylor TSinh DXObu HPhiri AMugri RMaxwell CRuano-Rubio VNyutu GKerasidou ALe SQManjurano ANjiragoma LMead DManning LCornelius VSadiq AOrimadegun AESirima SBYafi CdeVries JNewton COpi DHLin EReeder JMakani JRisley PAbathina AMarsh KFitzpatrick KJohnson KJStalker JBarry AOfori AOToure OReyburn HNadjm BEnimil ANyika ASirugo GNdila CMCeesay PLCasals-Pascual CMensah NCorran PDolo APotter CAnsah PAAmodu OO'Riordan SEGreen ABojang KALemnge MMalangone CSinghasivanon PRasheed OSissoko STroye-Blomberg MPearson RSaine HMai NTNtunthama NAsoala VHilton EAsafo-Agyei EAiyegbo MSimpore JAgbenyega TParker MSakuntabhai AYamoah LNyirongo VKokwaro GCamara AAtuguba FSylverken JMunthali ABamba KCamara LHodgson AVCarter RBusby GAnsah NASuriyaphol PDanso BDunstan SJLaman MApinjoh TODiss ASpencer CCWangai HGhansah AEvans JBougouma ECDewasurendra RCeesay NFernando DQuyen NTKwiatkowski DPOluoch TCampino SAmenga-Etego LNStevens MMarsh VSomaskantharajah ENdi AClark TGAuburn SOlaosebikan RMolyneux SKachala DRowlands KMacharia ADrury EDoyle AEsangbedo PPuijalon OKeita MLBarnwell DHart LAchidi EAFullah JMoore MMichon PSanJoaquin MHorstmann RKivinen KNjie HNjie JRockett KADuffy PNjie MShah SHieu NTVanderwal AEbonyi ANjie SSaidy-Khan MLy ABJeffreys AEO'Brien JKamuya DKonate SBand GBancone GSepulveda NMtove GMiotto OAnsong DConway DJHughes CPeshu NHutton RDjimde AHussein AAbubakar IPhu NHManske MMueller IDavis TMMacharia AWCook OWilliams TNCook KFarrar JIbrahim MIshengoma DOnykwelu ETaal BDiakite MWrigley RThera MARiley ESambou ICarucci DJammeh KDay NDoumbo OMaslen GMbunwe ETitanji VMoyes CTall AElhassan ADeloukas PPlowe CWilson MDDrakeley CElhassan ISall AHOduro ARPirinen MCorrea SVan Chuong LJallow MManneh LDiarra EAllen Ashelton JNiangaly AOlaniyan SDibba YOni OMangano VDHien TTCox SAllen SSmall KWatson RPensulo PClarke GMCole-Ceesay RHennsman MMutabingwa TJasseh MBauni ELeffler EKarunajeewa HTeo YYPinder MJyothi DMolloy SMalariaGEN ConsortiumMcCreight MHubbart CRagoussis IRagoussis JKanyi HKarunaweera NMacInnis BSiba PAmodu FAOuedraogo INOmotade OOAnchang-Kimbi JModiano DKoram KAChau TTGarcia JANkrumah FAkoto AOJoseph SUsen SSabally-Ceesay KCraik RKonate ATThai CQRogers JSimmons CPJobarteh AJaiteh JKhan AABull SMtei FMohamed HSambian DMiles ADe Silva NMolyneux MESisay-Joof FGottleib MRogers WOElzein AMendy ABesingi RfalseGlucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study.<h4>Background</h4>The global prevalence of X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is thought to be a result of selection by malaria, but epidemiological studies have yielded confusing results. We investigated the relationships between G6PD deficiency and both malaria and non-malarial illnesses among children in Kenya.<h4>Methods</h4>We did this study in Kilifi County, Kenya, where the G6PD c.202T allele is the only significant cause of G6PD deficiency. We tested the associations between G6PD deficiency and severe and complicated Plasmodium falciparum malaria through a case-control study of 2220 case and 3940 control children. Cases were children aged younger than 14 years, who visited the high dependency ward of Kilifi County Hospital with severe malaria between Marc2015-01-01T00:00:00Z2015 Oct2025-04-18T17:37:15.545Z2019-03-27T02:06:23ZS-EPMC47030472668604510.1016/S2352-3026(15)00152-0