biostudies-literaturePetrick JLIntramural NIH HHSNIDDK NIH HHSNHLBI NIH HHSNCI NIH HHS1156-62https://www.ebi.ac.uk/biostudies/studies/S-EPMC4704448biostudies-literatureUnknown8(12)Chronic inflammation plays a pivotal role in the pathogenesis of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), the two most common types of liver cancer. A number of prior experimental studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin and ibuprofen, may potentially protect against liver cancer. However, no observational study has examined the association between aspirin duration and dose or other over-the-counter non-aspirin NSAIDs, such as ibuprofen, and liver cancer incidence. Furthermore, the association between NSAID use and risk of ICC is unclear. As part of the Liver Cancer Pooling Project, we harmonized data on 1,084,133 individuals (HCC = 679, ICC = 225) from 10 U.S.-based prospective cohort studies. Cox proportCancer prevention research (Philadelphia, Pa.)NSAID Use and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: The Liver Cancer Pooling Project.PMC4704448DK098311UM1 CA182934CA87969UM1 CA182913R01 HL043851K24 DK098311P01 CA087969CA047988CA186107CA167552Z01 CP010158-07UM1 CA167552HL080467HL099355RC1 HL099355P30 CA060553UM1 CA164974R01 HL080467R01 CA047988UM1 CA186107Schairer CSesso HDWactawski-Wende JMcGlynn KAKing LYHollenbeck ARPalmer JRBeane-Freeman LEChong DQPetrick JLJacobs EJFreedman NDRosenberg LZeleniuch-Jacquotte AGraubard BIChan ATChen JBuring JELinet MSPurdue MPSahasrabuddhe VVAlavanja MCGiovannucci EHou LLee IMCampbell PTSigurdson AJFuchs CSKoshiol JGaziano JMfalseNSAID Use and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: The Liver Cancer Pooling Project.Chronic inflammation plays a pivotal role in the pathogenesis of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), the two most common types of liver cancer. A number of prior experimental studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin and ibuprofen, may potentially protect against liver cancer. However, no observational study has examined the association between aspirin duration and dose or other over-the-counter non-aspirin NSAIDs, such as ibuprofen, and liver cancer incidence. Furthermore, the association between NSAID use and risk of ICC is unclear. As part of the Liver Cancer Pooling Project, we harmonized data on 1,084,133 individuals (HCC = 679, ICC = 225) from 10 U.S.-based prospective cohort studies. Cox proport2015-01-01T00:00:00Z2015 Dec2025-04-22T07:15:05.496Z2019-03-27T02:06:28ZS-EPMC47044482639191710.1158/1940-6207.CAPR-15-012610.1158/1940-6207.capr-15-0126