{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bogdanova TI"],"funding":["Intramural NIH HHS","NCI NIH HHS"],"pagination":["1556-64"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4705885"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["113(11)"],"pubmed_abstract":["<h4>Background</h4>There are limited data on the histopathology of papillary thyroid carcinomas (PTCs) diagnosed in irradiated populations. We evaluated the associations between iodine-131 dose and the histopathological characteristics of post-Chernobyl PTCs, the changes in these characteristics over time, and their associations with selected somatic mutations.<h4>Methods</h4>This study included 115 PTCs diagnosed in a Ukrainian-American cohort (n=13,243) during prescreening and four successive thyroid screenings. Of these PTCs, 65 were subjected to somatic mutation profiling. All individuals were <18 years at the time of the Chernobyl accident and had direct thyroid radioactivity measurements. Statistical analyses included multivariate linear and logistic regression.<h4>Results</h4>We ide"],"journal":["British journal of cancer"],"pubmed_title":["Histopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort."],"pmcid":["PMC4705885"],"funding_grant_id":["R01 CA88041","CA132918","N01-CP-21178"],"pubmed_authors":["Bogdanova TI","Nikiforov YE","Shpak VM","Kovgan LM","McConnell RJ","Chanock S","Zurnadzhy LY","Tronko MD","Likhtarov IA","Drozdovitch V","Brenner AV","Zablotska LB","Hatch M","Mabuchi K","Little MP","Leeman-Neill RJ"],"additional_accession":[]},"is_claimable":false,"name":"Histopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort.","description":"<h4>Background</h4>There are limited data on the histopathology of papillary thyroid carcinomas (PTCs) diagnosed in irradiated populations. We evaluated the associations between iodine-131 dose and the histopathological characteristics of post-Chernobyl PTCs, the changes in these characteristics over time, and their associations with selected somatic mutations.<h4>Methods</h4>This study included 115 PTCs diagnosed in a Ukrainian-American cohort (n=13,243) during prescreening and four successive thyroid screenings. Of these PTCs, 65 were subjected to somatic mutation profiling. All individuals were <18 years at the time of the Chernobyl accident and had direct thyroid radioactivity measurements. Statistical analyses included multivariate linear and logistic regression.<h4>Results</h4>We ide","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Dec","modification":"2025-04-18T16:27:34.966Z","creation":"2019-03-27T02:06:33Z"},"accession":"S-EPMC4705885","cross_references":{"pubmed":["26625214"],"doi":["10.1038/bjc.2015.372"]}}