biostudies-literatureBogdanova TIIntramural NIH HHSNCI NIH HHS1556-64https://www.ebi.ac.uk/biostudies/studies/S-EPMC4705885biostudies-literatureUnknown113(11)<h4>Background</h4>There are limited data on the histopathology of papillary thyroid carcinomas (PTCs) diagnosed in irradiated populations. We evaluated the associations between iodine-131 dose and the histopathological characteristics of post-Chernobyl PTCs, the changes in these characteristics over time, and their associations with selected somatic mutations.<h4>Methods</h4>This study included 115 PTCs diagnosed in a Ukrainian-American cohort (n=13,243) during prescreening and four successive thyroid screenings. Of these PTCs, 65 were subjected to somatic mutation profiling. All individuals were <18 years at the time of the Chernobyl accident and had direct thyroid radioactivity measurements. Statistical analyses included multivariate linear and logistic regression.<h4>Results</h4>We ideBritish journal of cancerHistopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort.PMC4705885R01 CA88041CA132918N01-CP-21178Bogdanova TINikiforov YEShpak VMKovgan LMMcConnell RJChanock SZurnadzhy LYTronko MDLikhtarov IADrozdovitch VBrenner AVZablotska LBHatch MMabuchi KLittle MPLeeman-Neill RJfalseHistopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort.<h4>Background</h4>There are limited data on the histopathology of papillary thyroid carcinomas (PTCs) diagnosed in irradiated populations. We evaluated the associations between iodine-131 dose and the histopathological characteristics of post-Chernobyl PTCs, the changes in these characteristics over time, and their associations with selected somatic mutations.<h4>Methods</h4>This study included 115 PTCs diagnosed in a Ukrainian-American cohort (n=13,243) during prescreening and four successive thyroid screenings. Of these PTCs, 65 were subjected to somatic mutation profiling. All individuals were <18 years at the time of the Chernobyl accident and had direct thyroid radioactivity measurements. Statistical analyses included multivariate linear and logistic regression.<h4>Results</h4>We ide2015-01-01T00:00:00Z2015 Dec2025-04-18T16:27:34.966Z2019-03-27T02:06:33ZS-EPMC47058852662521410.1038/bjc.2015.372