{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(1)"],"submitter":["Gonzalez FB"],"pubmed_abstract":["The dynamics of regulatory T cells in the course of Trypanosoma cruzi infection is still debated. We previously demonstrated that acute murine T. cruzi infection results in an impaired peripheral CD4+Foxp3+ T cell differentiation due to the acquisition of an abnormal Th1-like phenotype and altered functional features, negatively impacting on the course of infection. Moreover, T. cruzi infection induces an intense thymic atrophy. As known, the thymus is the primary lymphoid organ in which thymic-derived regulatory T cells, known as tTregs, differentiate. Considering the lack of available data about the effect of T. cruzi infection upon tTregs, we examined tTreg dynamics during the course of disease. We confirmed that T. cruzi infection induces a marked loss of tTreg cell number associated t"],"journal":["PLoS neglected tropical diseases"],"pagination":["e0004285"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4706328"],"repository":["biostudies-literature"],"pubmed_title":["Trypanosoma cruzi Experimental Infection Impacts on the Thymic Regulatory T Cell Compartment."],"pmcid":["PMC4706328"],"pubmed_authors":["Spinelli SV","Gonzalez FB","Fernandez Bussy R","No Seara Cordeiro S","D'Attilio L","Calmon-Hamaty F","Villar SR","Savino W","Perez AR","Bottasso O","Cotta-de-Almeida V"],"additional_accession":[]},"is_claimable":false,"name":"Trypanosoma cruzi Experimental Infection Impacts on the Thymic Regulatory T Cell Compartment.","description":"The dynamics of regulatory T cells in the course of Trypanosoma cruzi infection is still debated. We previously demonstrated that acute murine T. cruzi infection results in an impaired peripheral CD4+Foxp3+ T cell differentiation due to the acquisition of an abnormal Th1-like phenotype and altered functional features, negatively impacting on the course of infection. Moreover, T. cruzi infection induces an intense thymic atrophy. As known, the thymus is the primary lymphoid organ in which thymic-derived regulatory T cells, known as tTregs, differentiate. Considering the lack of available data about the effect of T. cruzi infection upon tTregs, we examined tTreg dynamics during the course of disease. We confirmed that T. cruzi infection induces a marked loss of tTreg cell number associated t","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-18T16:27:52.806Z","creation":"2019-03-26T22:44:23Z"},"accession":"S-EPMC4706328","cross_references":{"pubmed":["26745276"],"doi":["10.1371/journal.pntd.0004285"]}}