biostudies-literatureLipert MPNIGMS NIH HHS4153-4163https://www.ebi.ac.uk/biostudies/studies/S-EPMC4706795biostudies-literatureUnknown104(12)This work examines cocrystal solubility in biorelevant media (FeSSIF, fed-state simulated intestinal fluid), and develops a theoretical framework that allows for the simple and quantitative prediction of cocrystal solubilization from drug solubilization. The solubilities of four hydrophobic drugs and seven cocrystals containing these drugs were measured in FeSSIF and in acetate buffer at pH 5.00. In all cases, the cocrystal solubility (Scocrystal ) was higher than the drug solubility (Sdrug ) in both buffer and FeSSIF; however, the solubilization ratio of drug, SRdrug = (SFeSSIF /Sbuffer )drug , was not the same as the solubilization ratio of cocrystal, SRcocrystal = (SFeSSIF /Sbuffer )cocrystal , meaning drug and cocrystal were not solubilized to the same extent in FeSSIF. This highlightsJournal of pharmaceutical sciencesCocrystal Solubilization in Biorelevant Media and its Prediction from Drug Solubilization.PMC4706795R01GM107146R01 GM107146Childs SLLipert MPRodriguez-Hornedo NRoy LfalseCocrystal Solubilization in Biorelevant Media and its Prediction from Drug Solubilization.This work examines cocrystal solubility in biorelevant media (FeSSIF, fed-state simulated intestinal fluid), and develops a theoretical framework that allows for the simple and quantitative prediction of cocrystal solubilization from drug solubilization. The solubilities of four hydrophobic drugs and seven cocrystals containing these drugs were measured in FeSSIF and in acetate buffer at pH 5.00. In all cases, the cocrystal solubility (Scocrystal ) was higher than the drug solubility (Sdrug ) in both buffer and FeSSIF; however, the solubilization ratio of drug, SRdrug = (SFeSSIF /Sbuffer )drug , was not the same as the solubilization ratio of cocrystal, SRcocrystal = (SFeSSIF /Sbuffer )cocrystal , meaning drug and cocrystal were not solubilized to the same extent in FeSSIF. This highlights2015-01-01T00:00:00Z2015 Dec2026-05-05T16:29:09.469Z2019-03-27T02:06:36ZS-EPMC47067952639021310.1002/jps.24640