{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garay J"],"funding":["BLRD VA","Louisiana Cancer Research Consortium","NIDDK NIH HHS","NCI NIH HHS","NIH","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["90-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4714604"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["371(1)"],"pubmed_abstract":["Infection with Helicobacter pylori (H. pylori) leads to inflammatory events that can promote gastric cancer development. Immune cells transition from the circulation into the infected mucosa through the interaction of their receptors and ligands in the endothelial compartment. CD44 expression is increased in advanced gastric lesions. However, the association of this molecule with the progression of these lesions over time has not been investigated. In addition, there is a lack of understanding of the CD44-dependent cellular processes that lead to gastritis, and possibly to gastric cancer. Here we studied H. pylori-positive subjects with gastric lesions that ranged from multifocal atrophic gastritis to dysplasia to determine gene expression changes associated with disease progression over a"],"journal":["Cancer letters"],"pubmed_title":["The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in mice."],"pmcid":["PMC4714604"],"funding_grant_id":["I01 BX001453","P01 CA028842","P20 GM103501","P20GM103501","P01 CA116087","P01-CA028842","P30 DK058404","R01 DK053620","P30 GM114732","R01 CA190612"],"pubmed_authors":["Del Valle L","Majumdar S","Zabaleta J","Trillo-Tinoco J","Correa P","Schneider BG","Delgado AG","Wilson KT","Piazuelo MB","Li L","Garay J"],"additional_accession":[]},"is_claimable":false,"name":"The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in mice.","description":"Infection with Helicobacter pylori (H. pylori) leads to inflammatory events that can promote gastric cancer development. Immune cells transition from the circulation into the infected mucosa through the interaction of their receptors and ligands in the endothelial compartment. CD44 expression is increased in advanced gastric lesions. However, the association of this molecule with the progression of these lesions over time has not been investigated. In addition, there is a lack of understanding of the CD44-dependent cellular processes that lead to gastritis, and possibly to gastric cancer. Here we studied H. pylori-positive subjects with gastric lesions that ranged from multifocal atrophic gastritis to dysplasia to determine gene expression changes associated with disease progression over a","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Feb","modification":"2025-04-19T08:32:26.66Z","creation":"2019-06-06T15:18:03Z"},"accession":"S-EPMC4714604","cross_references":{"pubmed":["26639196"],"doi":["10.1016/j.canlet.2015.10.037"]}}