{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bao Q"],"funding":["Canadian Institutes of Health Research","PHS HHS"],"pagination":["15516-15524"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4716812"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["118(28)"],"pubmed_abstract":["Platinum chemotherapeutic agents, such as cisplatin (<i>cis</i>-diamminedichloroplatinum(II)), can act as radiosensitizers when bound covalently to nuclear DNA in cancer cells. This radiosensitization is largely due to an increase in DNA damage induced by low-energy secondary electrons, produced in large quantities by high-energy radiation. We report the yields of single- and double-strand breaks (SSB and DSB) and interduplex cross-links (CL) induced by electrons of 1.6-19.6 eV (i.e., the yield functions) incident on 5 monolayer (ML) films of cisplatin-DNA complexes. These yield functions are compared with those previously recorded with 5 ML films of unmodified plasmid DNA. Binding of five cisplatin molecules to plasmid DNA (3197 base pairs) enhances SSB, DSB, and CL by factors varying, fr"],"journal":["The journal of physical chemistry. C, Nanomaterials and interfaces"],"pubmed_title":["Cisplatin Radiosensitization of DNA Irradiated with 2-20 eV Electrons: Role of Transient Anions."],"pmcid":["PMC4716812"],"funding_grant_id":["81356-2"],"pubmed_authors":["Zheng Y","Chen Y","Sanche L","Bao Q"],"additional_accession":[]},"is_claimable":false,"name":"Cisplatin Radiosensitization of DNA Irradiated with 2-20 eV Electrons: Role of Transient Anions.","description":"Platinum chemotherapeutic agents, such as cisplatin (<i>cis</i>-diamminedichloroplatinum(II)), can act as radiosensitizers when bound covalently to nuclear DNA in cancer cells. This radiosensitization is largely due to an increase in DNA damage induced by low-energy secondary electrons, produced in large quantities by high-energy radiation. We report the yields of single- and double-strand breaks (SSB and DSB) and interduplex cross-links (CL) induced by electrons of 1.6-19.6 eV (i.e., the yield functions) incident on 5 monolayer (ML) films of cisplatin-DNA complexes. These yield functions are compared with those previously recorded with 5 ML films of unmodified plasmid DNA. Binding of five cisplatin molecules to plasmid DNA (3197 base pairs) enhances SSB, DSB, and CL by factors varying, fr","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jun","modification":"2025-04-26T16:17:41.396Z","creation":"2019-03-26T22:59:46Z"},"accession":"S-EPMC4716812","cross_references":{"pubmed":["26793285"],"doi":["10.1021/jp503706h"]}}