{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(2)"],"submitter":["Korostishevsky M"],"funding":["National Institute for Health Research (NIHR)","Wellcome Trust"],"pubmed_abstract":["The contribution of specific molecular-genetic factors to muscle mass variation and sarcopenia remains largely unknown. To identify endogenous molecules and specific genetic factors associated with appendicular lean mass (APLM) in the general population, cross-sectional data from the TwinsUK Adult Twin Registry were used. Non-targeted mass spec-based metabolomic profiling was performed on plasma of 3953 females (mostly dizygotic and monozygotic twins). APLM was measured using dual-energy X-ray absorptiometry (DXA) and genotyping was genome-wide (GWAS). Specific metabolites were used as intermediate phenotypes in the identification of single-nucleotide polymorphisms associated with APLM using GWAS. In all, 162 metabolites were found significantly correlated with APLM, and explained 17.4% of"],"journal":["European journal of human genetics : EJHG"],"pagination":["277-83"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4717207"],"repository":["biostudies-literature"],"pubmed_title":["Genomics and metabolomics of muscular mass in a community-based sample of UK females."],"pmcid":["PMC4717207"],"pubmed_authors":["Korostishevsky M","Malkin I","Williams FM","Steves CJ","Livshits G","Spector T"],"additional_accession":[]},"is_claimable":false,"name":"Genomics and metabolomics of muscular mass in a community-based sample of UK females.","description":"The contribution of specific molecular-genetic factors to muscle mass variation and sarcopenia remains largely unknown. To identify endogenous molecules and specific genetic factors associated with appendicular lean mass (APLM) in the general population, cross-sectional data from the TwinsUK Adult Twin Registry were used. Non-targeted mass spec-based metabolomic profiling was performed on plasma of 3953 females (mostly dizygotic and monozygotic twins). APLM was measured using dual-energy X-ray absorptiometry (DXA) and genotyping was genome-wide (GWAS). Specific metabolites were used as intermediate phenotypes in the identification of single-nucleotide polymorphisms associated with APLM using GWAS. In all, 162 metabolites were found significantly correlated with APLM, and explained 17.4% of","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Feb","modification":"2026-05-05T18:39:34.481Z","creation":"2019-03-27T02:07:05Z"},"accession":"S-EPMC4717207","cross_references":{"pubmed":["25898920"],"doi":["10.1038/ejhg.2015.85"]}}