{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Abdelbaset-Ismail A"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS","National Institutes of Health"],"pagination":["134-46"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4717849"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Evidence has accumulated that murine haematopoietic stem/progenitor cells (HSPCs) share several markers with the germline, a connection supported by recent reports that pituitary and gonadal sex hormones (SexHs) regulate development of murine HSPCs. It has also been reported that human HSPCs, like their murine counterparts, respond to certain SexHs (e.g. androgens). However, to better address the effects of SexHs, particularly pituitary SexHs, on human haematopoiesis, we tested for expression of receptors for pituitary SexHs, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL), as well as the receptors for gonadal SexHs, including progesterone, oestrogens, and androgen, on HSPCs purified from human umbilical cord blood (UCB) and peripheral blood (PB)"],"journal":["Journal of cellular and molecular medicine"],"pubmed_title":["Human haematopoietic stem/progenitor cells express several functional sex hormone receptors."],"pmcid":["PMC4717849"],"funding_grant_id":["R01HL112788","2R01 DK074720","R01 DK074720","R01 HL112788"],"pubmed_authors":["Kucia M","Adamiak M","Abdelbaset-Ismail A","Suszynska M","Ratajczak J","Borkowska S","Ratajczak MZ"],"additional_accession":[]},"is_claimable":false,"name":"Human haematopoietic stem/progenitor cells express several functional sex hormone receptors.","description":"Evidence has accumulated that murine haematopoietic stem/progenitor cells (HSPCs) share several markers with the germline, a connection supported by recent reports that pituitary and gonadal sex hormones (SexHs) regulate development of murine HSPCs. It has also been reported that human HSPCs, like their murine counterparts, respond to certain SexHs (e.g. androgens). However, to better address the effects of SexHs, particularly pituitary SexHs, on human haematopoiesis, we tested for expression of receptors for pituitary SexHs, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL), as well as the receptors for gonadal SexHs, including progesterone, oestrogens, and androgen, on HSPCs purified from human umbilical cord blood (UCB) and peripheral blood (PB)","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-18T16:27:51.789Z","creation":"2019-03-27T02:07:06Z"},"accession":"S-EPMC4717849","cross_references":{"pubmed":["26515267"],"doi":["10.1111/jcmm.12712"]}}