{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Winuthayanon W"],"funding":["National Institute of Environmental Health Sciences","Intramural NIH HHS","PHS HHS"],"pagination":["e10453"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4718728"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4"],"pubmed_abstract":["Development of uterine endometrial receptivity for implantation is orchestrated by cyclic steroid hormone-mediated signals. It is unknown if these signals are necessary for oviduct function in supporting fertilization and preimplantation development. Here we show that conditional knockout (cKO) mice lacking estrogen receptor α (ERα) in oviduct and uterine epithelial cells have impaired fertilization due to a dramatic reduction in sperm migration. In addition, all successfully fertilized eggs die before the 2-cell stage due to persistence of secreted innate immune mediators including proteases. Elevated protease activity in cKO oviducts causes premature degradation of the zona pellucida and embryo lysis, and wild-type embryos transferred into cKO oviducts fail to develop normally unless res"],"journal":["eLife"],"pubmed_title":["Oviductal estrogen receptor α signaling prevents protease-mediated embryo death."],"pmcid":["PMC4718728"],"funding_grant_id":["1ZIAES70065","ZIA ES070065","ZIA ES050167","ZIA ES102405","1ZIAES025034","1ZIAES102405","ZIA ES025034","1ZIAES050167"],"pubmed_authors":["Winuthayanon W","Hewitt SC","Lih FB","Edin ML","Williams CJ","Padilla-Banks E","Bernhardt ML","Korach KS","Myers PH"],"additional_accession":[]},"is_claimable":false,"name":"Oviductal estrogen receptor α signaling prevents protease-mediated embryo death.","description":"Development of uterine endometrial receptivity for implantation is orchestrated by cyclic steroid hormone-mediated signals. It is unknown if these signals are necessary for oviduct function in supporting fertilization and preimplantation development. Here we show that conditional knockout (cKO) mice lacking estrogen receptor α (ERα) in oviduct and uterine epithelial cells have impaired fertilization due to a dramatic reduction in sperm migration. In addition, all successfully fertilized eggs die before the 2-cell stage due to persistence of secreted innate immune mediators including proteases. Elevated protease activity in cKO oviducts causes premature degradation of the zona pellucida and embryo lysis, and wild-type embryos transferred into cKO oviducts fail to develop normally unless res","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Dec","modification":"2026-06-14T03:17:55.188Z","creation":"2026-06-14T03:09:03.123Z"},"accession":"S-EPMC4718728","cross_references":{"pubmed":["26623518"],"doi":["10.7554/eLife.10453"]}}