{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shinn-Thomas JH"],"funding":["NICHD NIH HHS","NCRR NIH HHS","NIH HHS"],"pagination":["e0146874"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4723337"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["<h4>Background</h4>Regulatory and biophysical mechanisms of cell-cell fusion are largely unknown despite the fundamental requirement for fused cells in eukaryotic development. Only two cellular fusogens that are not of clear recent viral origin have been identified to date, both in nematodes. One of these, EFF-1, is necessary for most cell fusions in Caenorhabditis elegans. Unregulated EFF-1 expression causes lethality due to ectopic fusion between cells not developmentally programmed to fuse, highlighting the necessity of tight fusogen regulation for proper development. Identifying factors that regulate EFF-1 and its paralog AFF-1 could lead to discovery of molecular mechanisms that control cell fusion upstream of the action of a membrane fusogen. Bioinformatic analysis of the EFF-1A isof"],"journal":["PloS one"],"pubmed_title":["The EFF-1A Cytoplasmic Domain Influences Hypodermal Cell Fusions in C. elegans But Is Not Dependent on 14-3-3 Proteins."],"pmcid":["PMC4723337"],"funding_grant_id":["U54 RR022232","RR022232","R01 HD043156","HD043156","P40 OD010440"],"pubmed_authors":["del Campo JJ","Mohler WA","Shinn-Thomas JH","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"The EFF-1A Cytoplasmic Domain Influences Hypodermal Cell Fusions in C. elegans But Is Not Dependent on 14-3-3 Proteins.","description":"<h4>Background</h4>Regulatory and biophysical mechanisms of cell-cell fusion are largely unknown despite the fundamental requirement for fused cells in eukaryotic development. Only two cellular fusogens that are not of clear recent viral origin have been identified to date, both in nematodes. One of these, EFF-1, is necessary for most cell fusions in Caenorhabditis elegans. Unregulated EFF-1 expression causes lethality due to ectopic fusion between cells not developmentally programmed to fuse, highlighting the necessity of tight fusogen regulation for proper development. Identifying factors that regulate EFF-1 and its paralog AFF-1 could lead to discovery of molecular mechanisms that control cell fusion upstream of the action of a membrane fusogen. Bioinformatic analysis of the EFF-1A isof","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-05T11:48:01.186Z","creation":"2019-03-26T22:57:02Z"},"accession":"S-EPMC4723337","cross_references":{"pubmed":["26800457"],"doi":["10.1371/journal.pone.0146874"]}}