{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Geddes JM"],"funding":["Canadian Institutes of Health Research"],"pubmed_abstract":["<h4>Unlabelled</h4>The opportunistic fungal pathogen Cryptococcus neoformans causes life-threatening meningitis in immunocompromised individuals. The expression of virulence factors, including capsule and melanin, is in part regulated by the cyclic-AMP/protein kinase A (cAMP/PKA) signal transduction pathway. In this study, we investigated the influence of PKA on the composition of the intracellular proteome to obtain a comprehensive understanding of the regulation that underpins virulence. Through quantitative proteomics, enrichment and bioinformatic analyses, and an interactome study, we uncovered a pattern of PKA regulation for proteins associated with translation, the proteasome, metabolism, amino acid biosynthesis, and virulence-related functions. PKA regulation of the ubiquitin-protea"],"journal":["mBio"],"pagination":["e01862-15"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4725006"],"repository":["biostudies-literature"],"pubmed_title":["Analysis of the Protein Kinase A-Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation."],"pmcid":["PMC4725006"],"pubmed_authors":["Stoynov N","Caza M","Kronstad JW","Croll D","Foster LJ","Geddes JM"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of the Protein Kinase A-Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation.","description":"<h4>Unlabelled</h4>The opportunistic fungal pathogen Cryptococcus neoformans causes life-threatening meningitis in immunocompromised individuals. The expression of virulence factors, including capsule and melanin, is in part regulated by the cyclic-AMP/protein kinase A (cAMP/PKA) signal transduction pathway. In this study, we investigated the influence of PKA on the composition of the intracellular proteome to obtain a comprehensive understanding of the regulation that underpins virulence. Through quantitative proteomics, enrichment and bioinformatic analyses, and an interactome study, we uncovered a pattern of PKA regulation for proteins associated with translation, the proteasome, metabolism, amino acid biosynthesis, and virulence-related functions. PKA regulation of the ubiquitin-protea","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2026-05-05T20:15:35.735Z","creation":"2019-03-27T02:07:25Z"},"accession":"S-EPMC4725006","cross_references":{"pubmed":["26758180"],"doi":["10.1128/mBio.01862-15"]}}