{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["38(6)"],"submitter":["Paczkowska E"],"pubmed_abstract":["Context/objective
Traumatic spinal cord injury (SCI) leads to disruption of local vasculature inducing secondary damage of neural tissue. Circulating endothelial progenitor cells (EPCs) play an important role in post-injury regeneration of vasculature, whereas endothelial cells (ECs) reflect endothelial damage.Methods
Twenty patients with SCI were assessed during the first 24 hours, at day 3, and day 7 post-injury and compared to 25 healthy subjects. We herein investigated EPC and EC counts by flow cytometry as well as the levels of soluble factors (SDF-1, HGF, VEGF, Ang2, EGF, endoglin, PLGF, FGF-2, ET-1, BDNF, IGF-1) regulating their migration and proangiogenic function. To better characterize peripheral blood (PB) cells, global gene expression profiles of PB-derived cell"],"journal":["The journal of spinal cord medicine"],"pagination":["729-44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4725807"],"repository":["biostudies-literature"],"pubmed_title":["Evidence for proangiogenic cellular and humoral systemic response in patients with acute onset of spinal cord injury."],"pmcid":["PMC4725807"],"pubmed_authors":["Grzegrzolka R","Paczkowska E","Piecyk K","Dziedziejko V","Bohatyrewicz A","Roginska D","Jurewicz A","Machalinski B","Safranow K","Pius-Sadowska E"],"additional_accession":[]},"is_claimable":false,"name":"Evidence for proangiogenic cellular and humoral systemic response in patients with acute onset of spinal cord injury.","description":"Context/objective
Traumatic spinal cord injury (SCI) leads to disruption of local vasculature inducing secondary damage of neural tissue. Circulating endothelial progenitor cells (EPCs) play an important role in post-injury regeneration of vasculature, whereas endothelial cells (ECs) reflect endothelial damage.Methods
Twenty patients with SCI were assessed during the first 24 hours, at day 3, and day 7 post-injury and compared to 25 healthy subjects. We herein investigated EPC and EC counts by flow cytometry as well as the levels of soluble factors (SDF-1, HGF, VEGF, Ang2, EGF, endoglin, PLGF, FGF-2, ET-1, BDNF, IGF-1) regulating their migration and proangiogenic function. To better characterize peripheral blood (PB) cells, global gene expression profiles of PB-derived cell","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Nov","modification":"2025-04-19T08:34:04.001Z","creation":"2019-03-27T02:07:27Z"},"accession":"S-EPMC4725807","cross_references":{"pubmed":["24968203"],"doi":["10.1179/2045772314y.0000000227","10.1179/2045772314Y.0000000227"]}}