biostudies-literatureUnknown38(6)Paczkowska E<h4>Context/objective</h4>Traumatic spinal cord injury (SCI) leads to disruption of local vasculature inducing secondary damage of neural tissue. Circulating endothelial progenitor cells (EPCs) play an important role in post-injury regeneration of vasculature, whereas endothelial cells (ECs) reflect endothelial damage.<h4>Methods</h4>Twenty patients with SCI were assessed during the first 24 hours, at day 3, and day 7 post-injury and compared to 25 healthy subjects. We herein investigated EPC and EC counts by flow cytometry as well as the levels of soluble factors (SDF-1, HGF, VEGF, Ang2, EGF, endoglin, PLGF, FGF-2, ET-1, BDNF, IGF-1) regulating their migration and proangiogenic function. To better characterize peripheral blood (PB) cells, global gene expression profiles of PB-derived cellThe journal of spinal cord medicine729-44https://www.ebi.ac.uk/biostudies/studies/S-EPMC4725807biostudies-literatureEvidence for proangiogenic cellular and humoral systemic response in patients with acute onset of spinal cord injury.PMC4725807Grzegrzolka RPaczkowska EPiecyk KDziedziejko VBohatyrewicz ARoginska DJurewicz AMachalinski BSafranow KPius-Sadowska EfalseEvidence for proangiogenic cellular and humoral systemic response in patients with acute onset of spinal cord injury.<h4>Context/objective</h4>Traumatic spinal cord injury (SCI) leads to disruption of local vasculature inducing secondary damage of neural tissue. Circulating endothelial progenitor cells (EPCs) play an important role in post-injury regeneration of vasculature, whereas endothelial cells (ECs) reflect endothelial damage.<h4>Methods</h4>Twenty patients with SCI were assessed during the first 24 hours, at day 3, and day 7 post-injury and compared to 25 healthy subjects. We herein investigated EPC and EC counts by flow cytometry as well as the levels of soluble factors (SDF-1, HGF, VEGF, Ang2, EGF, endoglin, PLGF, FGF-2, ET-1, BDNF, IGF-1) regulating their migration and proangiogenic function. To better characterize peripheral blood (PB) cells, global gene expression profiles of PB-derived cell2015-01-01T00:00:00Z2015 Nov2025-04-19T08:34:04.001Z2019-03-27T02:07:27ZS-EPMC47258072496820310.1179/2045772314y.000000022710.1179/2045772314Y.0000000227