{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Gwak R"],"pubmed_abstract":["Uranium is an essential raw material in nuclear energy generation; however, its use raises concerns about the possibility of severe damage to human health and the natural environment. In this work, we report an ultrasensitive uranyl ion (UO2(2+)) detection method in natural water that uses a plasmonic nanowire interstice (PNI) sensor combined with a DNAzyme-cleaved reaction. UO2(2+) induces the cleavage of DNAzymes into enzyme strands and released strands, which include Raman-active molecules. A PNI sensor can capture the released strands, providing strong surface-enhanced Raman scattering signal. The combination of a PNI sensor and a DNAzyme-cleaved reaction significantly improves the UO2(2+) detection performance, resulting in a detection limit of 1 pM and high selectivity. More importantly, the PNI sensor operates perfectly, even in UO2(2+)-contaminated natural water samples. This suggests the potential usefulness of a PNI sensor in practical UO2(2+)-sensing applications. We anticipate that diverse toxic metal ions can be detected by applying various ion-specific DNA-based ligands to PNI sensors."],"journal":["Scientific reports"],"pagination":["19646"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4726367"],"repository":["biostudies-literature"],"pubmed_title":["Precisely Determining Ultralow level UO2(2+) in Natural Water with Plasmonic Nanowire Interstice Sensor."],"pmcid":["PMC4726367"],"pubmed_authors":["Kim B","Lee SY","Kim H","Rhee CK","Kang T","Lee GJ","Lee MK","Gwak R","Yoo SM"],"additional_accession":[]},"is_claimable":false,"name":"Precisely Determining Ultralow level UO2(2+) in Natural Water with Plasmonic Nanowire Interstice Sensor.","description":"Uranium is an essential raw material in nuclear energy generation; however, its use raises concerns about the possibility of severe damage to human health and the natural environment. In this work, we report an ultrasensitive uranyl ion (UO2(2+)) detection method in natural water that uses a plasmonic nanowire interstice (PNI) sensor combined with a DNAzyme-cleaved reaction. UO2(2+) induces the cleavage of DNAzymes into enzyme strands and released strands, which include Raman-active molecules. A PNI sensor can capture the released strands, providing strong surface-enhanced Raman scattering signal. The combination of a PNI sensor and a DNAzyme-cleaved reaction significantly improves the UO2(2+) detection performance, resulting in a detection limit of 1 pM and high selectivity. More importantly, the PNI sensor operates perfectly, even in UO2(2+)-contaminated natural water samples. This suggests the potential usefulness of a PNI sensor in practical UO2(2+)-sensing applications. We anticipate that diverse toxic metal ions can be detected by applying various ion-specific DNA-based ligands to PNI sensors.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2021-02-21T02:34:49Z","creation":"2019-03-27T02:07:32Z"},"accession":"S-EPMC4726367","cross_references":{"pubmed":["26791784"],"doi":["10.1038/srep19646"]}}