{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Preisitsch M"],"pubmed_abstract":["In this study, the influence of halide ions on [7.7]paracyclophane biosynthesis in the cyanobacterium Nostoc sp. CAVN2 was investigated. In contrast to KI and KF, supplementation of the culture medium with KCl or KBr resulted not only in an increase of growth but also in an up-regulation of carbamidocyclophane production. LC-MS analysis indicated the presence of chlorinated, brominated, but also non-halogenated derivatives. In addition to 22 known cylindrocyclophanes and carbamidocyclophanes, 27 putative congeners have been detected. Nine compounds, carbamidocyclophanes M-U, were isolated, and their structural elucidation by 1D and 2D NMR experiments in combination with HRMS and ECD analysis revealed that they are brominated analogues of chlorinated carbamidocyclophanes. Quantification of "],"journal":["Marine drugs"],"pagination":["21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4728517"],"repository":["biostudies-literature"],"pubmed_title":["Effects of Halide Ions on the Carbamidocyclophane Biosynthesis in Nostoc sp. CAVN2."],"pmcid":["PMC4728517"],"pubmed_authors":["Beerbaum M","Schmieder P","Herrmann J","Kumpfmuller J","Muller R","Bange FC","Daniel R","Mundt S","Niedermeyer TH","Schweder T","Neidhardt I","Wiesner C","Thurmer A","Schneefeld M","Heiden SE","Preisitsch M"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Halide Ions on the Carbamidocyclophane Biosynthesis in Nostoc sp. CAVN2.","description":"In this study, the influence of halide ions on [7.7]paracyclophane biosynthesis in the cyanobacterium Nostoc sp. CAVN2 was investigated. In contrast to KI and KF, supplementation of the culture medium with KCl or KBr resulted not only in an increase of growth but also in an up-regulation of carbamidocyclophane production. LC-MS analysis indicated the presence of chlorinated, brominated, but also non-halogenated derivatives. In addition to 22 known cylindrocyclophanes and carbamidocyclophanes, 27 putative congeners have been detected. Nine compounds, carbamidocyclophanes M-U, were isolated, and their structural elucidation by 1D and 2D NMR experiments in combination with HRMS and ECD analysis revealed that they are brominated analogues of chlorinated carbamidocyclophanes. Quantification of ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2026-05-05T18:49:43.118Z","creation":"2019-03-27T02:07:38Z"},"accession":"S-EPMC4728517","cross_references":{"pubmed":["26805858"],"doi":["10.3390/md14010021"]}}