{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Palmerini CA"],"pubmed_abstract":["A salivary proline-rich peptide of 1932 Da showed a dose-dependent antagonistic effect on the cytosolic Ca2+ mobilization induced by progesterone in a tongue squamous carcinoma cell line. Structure-activity studies showed that the activity of the peptide resides in the C-terminal region characterized by a proline stretch flanked by basic residues. Furthermore, lack of activity of the retro-inverso peptide analogue suggested the involvement of stereospecific recognition. Mass spectrometry-based shotgun analysis, combined with Western blotting tests and biochemical data obtained with the Progesterone Receptor Membrane Component 1 (PGRMC1) inhibitor AG205, showed strong evidence that p1932 performs its modulatory action through an interaction with the progesterone receptor PGRMC1, which is pr"],"journal":["PloS one"],"pagination":["e0147925"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4729474"],"repository":["biostudies-literature"],"pubmed_title":["Antagonistic Effect of a Salivary Proline-Rich Peptide on the Cytosolic Ca2+ Mobilization Induced by Progesterone in Oral Squamous Cancer Cells."],"pmcid":["PMC4729474"],"pubmed_authors":["Longhi R","Vitali A","Iavarone F","Messana I","Castagnola M","Radicioni G","Sanna MT","Palmerini CA","Marzano V","Mazzoni M","Cabras T","Granieri L"],"additional_accession":[]},"is_claimable":false,"name":"Antagonistic Effect of a Salivary Proline-Rich Peptide on the Cytosolic Ca2+ Mobilization Induced by Progesterone in Oral Squamous Cancer Cells.","description":"A salivary proline-rich peptide of 1932 Da showed a dose-dependent antagonistic effect on the cytosolic Ca2+ mobilization induced by progesterone in a tongue squamous carcinoma cell line. Structure-activity studies showed that the activity of the peptide resides in the C-terminal region characterized by a proline stretch flanked by basic residues. Furthermore, lack of activity of the retro-inverso peptide analogue suggested the involvement of stereospecific recognition. Mass spectrometry-based shotgun analysis, combined with Western blotting tests and biochemical data obtained with the Progesterone Receptor Membrane Component 1 (PGRMC1) inhibitor AG205, showed strong evidence that p1932 performs its modulatory action through an interaction with the progesterone receptor PGRMC1, which is pr","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-05-29T22:23:36.671Z","creation":"2019-03-26T22:57:05Z"},"accession":"S-EPMC4729474","cross_references":{"pubmed":["26814504"],"doi":["10.1371/journal.pone.0147925"]}}