{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Carbone AL"],"pubmed_abstract":["Glutamate receptors form complexes in the brain with auxiliary proteins, which control their activity during fast synaptic transmission through a seemingly bewildering array of effects. Here we devise a way to isolate the activation of complexes using polyamines, which enables us to show that transmembrane AMPA receptor regulatory proteins (TARPs) exert their effects principally on the channel opening reaction. A thermodynamic argument suggests that because TARPs promote channel opening, receptor activation promotes AMPAR-TARP complexes into a superactive state with high open probability. A simple model based on this idea predicts all known effects of TARPs on AMPA receptor function. This model also predicts unexpected phenomena including massive potentiation in the absence of desensitizat"],"journal":["Nature communications"],"pagination":["10178"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4729862"],"repository":["biostudies-literature"],"pubmed_title":["Superactivation of AMPA receptors by auxiliary proteins."],"pmcid":["PMC4729862"],"pubmed_authors":["Plested AJ","Carbone AL"],"additional_accession":[]},"is_claimable":false,"name":"Superactivation of AMPA receptors by auxiliary proteins.","description":"Glutamate receptors form complexes in the brain with auxiliary proteins, which control their activity during fast synaptic transmission through a seemingly bewildering array of effects. Here we devise a way to isolate the activation of complexes using polyamines, which enables us to show that transmembrane AMPA receptor regulatory proteins (TARPs) exert their effects principally on the channel opening reaction. A thermodynamic argument suggests that because TARPs promote channel opening, receptor activation promotes AMPAR-TARP complexes into a superactive state with high open probability. A simple model based on this idea predicts all known effects of TARPs on AMPA receptor function. This model also predicts unexpected phenomena including massive potentiation in the absence of desensitizat","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-04T03:42:26.688Z","creation":"2019-03-27T02:07:42Z"},"accession":"S-EPMC4729862","cross_references":{"pubmed":["26744192"],"doi":["10.1038/ncomms10178"]}}