{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McDonald PW"],"funding":["NIAID NIH HHS"],"pagination":["10285"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4729877"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7"],"pubmed_abstract":["The transcriptional repressor Bcl-6 is linked to the development of both CD4(+) T follicular helper (TFH) and central memory T (TCM) cells. Here, we demonstrate that in response to decreased IL-2 signalling, T helper 1 (TH1) cells upregulate Bcl-6 and co-initiate TFH- and TCM-like gene programs, including expression of the cytokine receptors IL-6Rα and IL-7R. Exposure of this potentially bi-potent cell population to IL-6 favours the TFH gene program, whereas IL-7 signalling represses TFH-associated genes including Bcl6 and Cxcr5, but not the TCM-related genes Klf2 and Sell. Mechanistically, IL-7-dependent activation of STAT5 contributes to Bcl-6 repression. Importantly, antigen-specific IL-6Rα(+)IL-7R(+) CD4(+) T cells emerge from the effector population at late time points post influenza "],"journal":["Nature communications"],"pubmed_title":["IL-7 signalling represses Bcl-6 and the TFH gene program."],"pmcid":["PMC4729877"],"funding_grant_id":["R01 AI110480"],"pubmed_authors":["Ballesteros-Tato A","Anderson AE","McDonald PW","Oestreich KJ","Read KA","Baker CE","Powell MD"],"additional_accession":[]},"is_claimable":false,"name":"IL-7 signalling represses Bcl-6 and the TFH gene program.","description":"The transcriptional repressor Bcl-6 is linked to the development of both CD4(+) T follicular helper (TFH) and central memory T (TCM) cells. Here, we demonstrate that in response to decreased IL-2 signalling, T helper 1 (TH1) cells upregulate Bcl-6 and co-initiate TFH- and TCM-like gene programs, including expression of the cytokine receptors IL-6Rα and IL-7R. Exposure of this potentially bi-potent cell population to IL-6 favours the TFH gene program, whereas IL-7 signalling represses TFH-associated genes including Bcl6 and Cxcr5, but not the TCM-related genes Klf2 and Sell. Mechanistically, IL-7-dependent activation of STAT5 contributes to Bcl-6 repression. Importantly, antigen-specific IL-6Rα(+)IL-7R(+) CD4(+) T cells emerge from the effector population at late time points post influenza ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-04T03:42:30.683Z","creation":"2019-03-27T02:07:43Z"},"accession":"S-EPMC4729877","cross_references":{"pubmed":["26743592"],"doi":["10.1038/ncomms10285"]}}