{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(1)"],"submitter":["Yang Y"],"pubmed_abstract":["As a chronic disorder, insomnia affects approximately 10% of the population at some time during their lives, and its treatment is often challenging. Since the antagonists of the H₁ receptor, a protein prevalent in human central nervous system, have been proven as effective therapeutic agents for treating insomnia, the H₁ receptor is quite possibly a promising target for developing potent anti-insomnia drugs. For the purpose of understanding the structural actors affecting the antagonism potency, presently a theoretical research of molecular interactions between 129 molecules and the H₁ receptor is performed through three-dimensional quantitative structure-activity relationship (3D-QSAR) techniques. The ligand-based comparative molecular similarity indices analysis (CoMSIA) model (Q² = 0.52"],"journal":["International journal of molecular sciences"],"pagination":["E129"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4730370"],"repository":["biostudies-literature"],"pubmed_title":["Computational Analysis of Structure-Based Interactions for Novel H₁-Antihistamines."],"pmcid":["PMC4730370"],"pubmed_authors":["Li Y","Yang Y","Pan Y","Yang L","Wang C","Lin F","Zhang S","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Computational Analysis of Structure-Based Interactions for Novel H₁-Antihistamines.","description":"As a chronic disorder, insomnia affects approximately 10% of the population at some time during their lives, and its treatment is often challenging. Since the antagonists of the H₁ receptor, a protein prevalent in human central nervous system, have been proven as effective therapeutic agents for treating insomnia, the H₁ receptor is quite possibly a promising target for developing potent anti-insomnia drugs. For the purpose of understanding the structural actors affecting the antagonism potency, presently a theoretical research of molecular interactions between 129 molecules and the H₁ receptor is performed through three-dimensional quantitative structure-activity relationship (3D-QSAR) techniques. The ligand-based comparative molecular similarity indices analysis (CoMSIA) model (Q² = 0.52","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2026-05-05T08:09:45.148Z","creation":"2026-04-07T21:31:34.594Z"},"accession":"S-EPMC4730370","cross_references":{"pubmed":["26797608"],"doi":["10.3390/ijms17010129"]}}