{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cook KD"],"funding":["North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill","University of North Carolina","NIAID NIH HHS","NINDS NIH HHS","NCI NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["703-14"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4731234"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(4)"],"pubmed_abstract":["Epigenetic changes, including histone methylation, control T cell differentiation and memory formation, though the enzymes that mediate these processes are not clear. We show that UTX, a histone H3 lysine 27 (H3K27) demethylase, supports T follicular helper (Tfh) cell responses that are essential for B cell antibody generation and the resolution of chronic viral infections. Mice with a T cell-specific UTX deletion had fewer Tfh cells, reduced germinal center responses, lacked virus-specific immunoglobulin G (IgG), and were unable to resolve chronic lymphocytic choriomeningitis virus infections. UTX-deficient T cells showed decreased expression of interleukin-6 receptor-α and other Tfh cell-related genes that were associated with increased H3K27 methylation. Additionally, Turner Syndrome su"],"journal":["Immunity"],"pubmed_title":["T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX."],"pmcid":["PMC4731234"],"funding_grant_id":["R56 AI110682","R01 NS079683","P30 CA016086","T32 AI007273","R01 GM101974","TTSA004P2","R01 GM10974","R01 AI074862","T32 AI7273-27"],"pubmed_authors":["Whitfield-Larry F","Allard DE","Rager JE","Fry RC","Su MA","Magnuson T","Whitmire JK","Cook KD","Conley B","Shpargel KB","Starmer J","Davenport ML"],"additional_accession":[]},"is_claimable":false,"name":"T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.","description":"Epigenetic changes, including histone methylation, control T cell differentiation and memory formation, though the enzymes that mediate these processes are not clear. We show that UTX, a histone H3 lysine 27 (H3K27) demethylase, supports T follicular helper (Tfh) cell responses that are essential for B cell antibody generation and the resolution of chronic viral infections. Mice with a T cell-specific UTX deletion had fewer Tfh cells, reduced germinal center responses, lacked virus-specific immunoglobulin G (IgG), and were unable to resolve chronic lymphocytic choriomeningitis virus infections. UTX-deficient T cells showed decreased expression of interleukin-6 receptor-α and other Tfh cell-related genes that were associated with increased H3K27 methylation. Additionally, Turner Syndrome su","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Oct","modification":"2025-04-04T01:17:40.696Z","creation":"2019-03-27T02:07:47Z"},"accession":"S-EPMC4731234","cross_references":{"pubmed":["26431949"],"doi":["10.1016/j.immuni.2015.09.002"]}}