biostudies-literatureCook KDNorth Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel HillUniversity of North CarolinaNIAID NIH HHSNINDS NIH HHSNCI NIH HHSNational Institutes of HealthNIGMS NIH HHS703-14https://www.ebi.ac.uk/biostudies/studies/S-EPMC4731234biostudies-literatureUnknown43(4)Epigenetic changes, including histone methylation, control T cell differentiation and memory formation, though the enzymes that mediate these processes are not clear. We show that UTX, a histone H3 lysine 27 (H3K27) demethylase, supports T follicular helper (Tfh) cell responses that are essential for B cell antibody generation and the resolution of chronic viral infections. Mice with a T cell-specific UTX deletion had fewer Tfh cells, reduced germinal center responses, lacked virus-specific immunoglobulin G (IgG), and were unable to resolve chronic lymphocytic choriomeningitis virus infections. UTX-deficient T cells showed decreased expression of interleukin-6 receptor-α and other Tfh cell-related genes that were associated with increased H3K27 methylation. Additionally, Turner Syndrome suImmunityT Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.PMC4731234R56 AI110682R01 NS079683P30 CA016086T32 AI007273R01 GM101974TTSA004P2R01 GM10974R01 AI074862T32 AI7273-27Whitfield-Larry FAllard DERager JEFry RCSu MAMagnuson TWhitmire JKCook KDConley BShpargel KBStarmer JDavenport MLfalseT Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.Epigenetic changes, including histone methylation, control T cell differentiation and memory formation, though the enzymes that mediate these processes are not clear. We show that UTX, a histone H3 lysine 27 (H3K27) demethylase, supports T follicular helper (Tfh) cell responses that are essential for B cell antibody generation and the resolution of chronic viral infections. Mice with a T cell-specific UTX deletion had fewer Tfh cells, reduced germinal center responses, lacked virus-specific immunoglobulin G (IgG), and were unable to resolve chronic lymphocytic choriomeningitis virus infections. UTX-deficient T cells showed decreased expression of interleukin-6 receptor-α and other Tfh cell-related genes that were associated with increased H3K27 methylation. Additionally, Turner Syndrome su2015-01-01T00:00:00Z2015 Oct2025-04-04T01:17:40.696Z2019-03-27T02:07:47ZS-EPMC47312342643194910.1016/j.immuni.2015.09.002