{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Shi H"],"pubmed_abstract":["Lanatoside C's impact on atherosclerosis is poorly understood. The present study was conducted to determine whether lanatoside C affects the development of atherosclerosis in apolipoprotein E-deficient (ApoE(-/-)) mice. ApoE(-/-) mice were administered either phosphate-buffered saline (PBS) containing 0.1% DMSO (the vehicle control group) or lanatoside C at low (1 mg/kg per day) or high (2 mg/kg per day) doses, and fed a Western diet for 12 weeks. Lanatoside C dose-dependently aggravated the development of atherosclerosis in the ApoE(-/-) mice compared with the vehicle control group. In an effort to determine the mechanism by which lanatoside C increased atherosclerosis, we found that lanatoside C significantly promoted the uptake of oxidised low-density lipoprotein (oxLDL) and increased f"],"journal":["Scientific reports"],"pagination":["20154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4731744"],"repository":["biostudies-literature"],"pubmed_title":["Lanatoside C Promotes Foam Cell Formation and Atherosclerosis."],"pmcid":["PMC4731744"],"pubmed_authors":["Liu Y","Zeng Q","Zhu J","Mao X","Zhong Y","Zhu R","Sun H","Yu K","Wei Y","Shi H","Mao Y","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"Lanatoside C Promotes Foam Cell Formation and Atherosclerosis.","description":"Lanatoside C's impact on atherosclerosis is poorly understood. The present study was conducted to determine whether lanatoside C affects the development of atherosclerosis in apolipoprotein E-deficient (ApoE(-/-)) mice. ApoE(-/-) mice were administered either phosphate-buffered saline (PBS) containing 0.1% DMSO (the vehicle control group) or lanatoside C at low (1 mg/kg per day) or high (2 mg/kg per day) doses, and fed a Western diet for 12 weeks. Lanatoside C dose-dependently aggravated the development of atherosclerosis in the ApoE(-/-) mice compared with the vehicle control group. In an effort to determine the mechanism by which lanatoside C increased atherosclerosis, we found that lanatoside C significantly promoted the uptake of oxidised low-density lipoprotein (oxLDL) and increased f","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-22T11:45:15.062Z","creation":"2019-03-27T02:07:48Z"},"accession":"S-EPMC4731744","cross_references":{"pubmed":["26821916"],"doi":["10.1038/srep20154"]}}