biostudies-literatureUnknown16Bucher J<h4>Background</h4>Viral infections such as influenza are thought to impact respiratory parameters and to promote infection with Pseudomonas aeruginosa in patients with cystic fibrosis (CF). However, the real morbidity of the influenza virus in CF needs to be further investigated because previous studies were only observational.<h4>Methods</h4>CF patients were included in a case-control study (n = 44 cases and n = 371 controls) during the 2009 pandemic A/H1N1 influenza. Cases were patients with polymerase reaction chain-confirmed influenza A/H1N1 infection. Controls did not report any influenza symptoms during the same period. Sputum colonization and lung function were monitored during 1 year after inclusion.<h4>Results</h4>Cases were significantly younger than controls (mean(SD) 14.9 yearBMC infectious diseases55https://www.ebi.ac.uk/biostudies/studies/S-EPMC4736161biostudies-literatureLessons from a French collaborative case-control study in cystic fibrosis patients during the 2009 A/H1N1 influenza pandemy.PMC4736161Vodoff MVStremler NBoussaud VDelaisi BBassinet LSermet-Gaudelus ICorvol HDurieu IDeneuville ERemus NTroussier FLaunay OBucher JLebourgeois MBremont FBoelle PYGrenet DTreluyer JMHubert DLeruez-Ville MfalseLessons from a French collaborative case-control study in cystic fibrosis patients during the 2009 A/H1N1 influenza pandemy.<h4>Background</h4>Viral infections such as influenza are thought to impact respiratory parameters and to promote infection with Pseudomonas aeruginosa in patients with cystic fibrosis (CF). However, the real morbidity of the influenza virus in CF needs to be further investigated because previous studies were only observational.<h4>Methods</h4>CF patients were included in a case-control study (n = 44 cases and n = 371 controls) during the 2009 pandemic A/H1N1 influenza. Cases were patients with polymerase reaction chain-confirmed influenza A/H1N1 infection. Controls did not report any influenza symptoms during the same period. Sputum colonization and lung function were monitored during 1 year after inclusion.<h4>Results</h4>Cases were significantly younger than controls (mean(SD) 14.9 year2016-01-01T00:00:00Z2016 Feb2025-04-19T01:40:00.141Z2019-03-27T02:08:03ZS-EPMC47361612683033510.1186/s12879-016-1352-2