biostudies-literatureLangton MJEPSRC CentreFunded AccessEuropean Union’s Framework ProgramEuropean Research CouncilUniversity of Oxford Clarendon Fund ScholarshipEPSRCEngineering and Physical Sciences Research Council18910-4https://www.ebi.ac.uk/biostudies/studies/S-EPMC4736451biostudies-literatureUnknown21(52)The synthesis of an all-halogen-bonding rotaxane for anion recognition is achieved by using active-metal templation. A flexible bis-iodotriazole-containing macrocycle is exploited for the metal-directed rotaxane synthesis. Endotopic binding of a Cu(I) template facilitates an active-metal CuAAC iodotriazole axle formation reaction that captures the interlocked rotaxane product. Following copper-template removal, exotopic coordination of a more sterically demanding rhenium(I) complex induces an inversion in the conformation of the macrocycle component, directing the iodotriazole halogen-bond donors into the rotaxane's interlocked binding cavity to facilitate anion recognition.Chemistry (Weinheim an der Bergstrasse, Germany)Active-Metal Template Synthesis of a Halogen-Bonding Rotaxane for Anion Recognition.PMC47364512674261517513FP7/2007-2013EP/L015838/1Xiong YLangton MJBeer PDfalseActive-Metal Template Synthesis of a Halogen-Bonding Rotaxane for Anion Recognition.The synthesis of an all-halogen-bonding rotaxane for anion recognition is achieved by using active-metal templation. A flexible bis-iodotriazole-containing macrocycle is exploited for the metal-directed rotaxane synthesis. Endotopic binding of a Cu(I) template facilitates an active-metal CuAAC iodotriazole axle formation reaction that captures the interlocked rotaxane product. Following copper-template removal, exotopic coordination of a more sterically demanding rhenium(I) complex induces an inversion in the conformation of the macrocycle component, directing the iodotriazole halogen-bond donors into the rotaxane's interlocked binding cavity to facilitate anion recognition.2015-01-01T00:00:00Z2015 Dec2026-05-05T09:05:10.49Z2019-03-27T02:08:03ZS-EPMC47364512650015010.1002/chem.201504236