{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li S"],"funding":["Howard Hughes Medical Institute","NIGMS NIH HHS"],"pagination":["608-20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4737185"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(2)"],"pubmed_abstract":["Transposable elements are found throughout the genomes of all organisms. Repressive marks such as DNA methylation and histone H3 lysine 9 (H3K9) methylation silence these elements and maintain genome integrity. However, how silencing mechanisms are themselves regulated to avoid the silencing of genes remains unclear. Here, an anti-silencing factor was identified using a forward genetic screen on a reporter line that harbors a LUCIFERASE (LUC) gene driven by a promoter that undergoes DNA methylation. SUVH1, a Su(var)3-9 homolog, was identified as a factor promoting the expression of the LUC gene. Treatment with a cytosine methylation inhibitor completely suppressed the LUC expression defects of suvh1, indicating that SUVH1 is dispensable for LUC expression in the absence of DNA methylation."],"journal":["Nucleic acids research"],"pubmed_title":["SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation."],"pmcid":["PMC4737185"],"funding_grant_id":["GM061146","R01 GM061146"],"pubmed_authors":["Li S","Liu L","Gao L","Kim YJ","Chen X","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation.","description":"Transposable elements are found throughout the genomes of all organisms. Repressive marks such as DNA methylation and histone H3 lysine 9 (H3K9) methylation silence these elements and maintain genome integrity. However, how silencing mechanisms are themselves regulated to avoid the silencing of genes remains unclear. Here, an anti-silencing factor was identified using a forward genetic screen on a reporter line that harbors a LUCIFERASE (LUC) gene driven by a promoter that undergoes DNA methylation. SUVH1, a Su(var)3-9 homolog, was identified as a factor promoting the expression of the LUC gene. Treatment with a cytosine methylation inhibitor completely suppressed the LUC expression defects of suvh1, indicating that SUVH1 is dispensable for LUC expression in the absence of DNA methylation.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2026-05-05T20:04:31.966Z","creation":"2019-03-27T02:08:06Z"},"accession":"S-EPMC4737185","cross_references":{"pubmed":["26400170"],"doi":["10.1093/nar/gkv958"]}}