biostudies-literatureGodefroy ONIA NIH HHS51-62https://www.ebi.ac.uk/biostudies/studies/S-EPMC4737650biostudies-literatureUnknown54<h4>Introduction</h4>Although accurate diagnosis of deficit of mild intensity is critical, various methods are used to assess, dichotomize and integrate performance, with no validated gold standard. This study described and validated a framework for the analysis of cognitive performance.<h4>Methods</h4>This study was performed by using the Groupe de Réflexion sur L'Evaluation des Fonctions EXécutives (GREFEX) database (724 controls and 461 patients) examined by 7 tests assessing executive functions. The first phase determined the criteria for the cutoff scores, the second phase, the effect of test number on diagnostic accuracy and the third phase, the best methods for combining test scores into an overall summary score. Four validation criteria were used: determination of impaired performaCortex; a journal devoted to the study of the nervous system and behaviorValidation of an integrated method for determining cognitive ability: Implications for routine assessments and clinical trials.PMC4737650P50 AG005136Bertola CBellmann ALabauge PHannequin DGREFEX study groupJoseph PARenou PPollack PDiouf MVerny MVuadens PAzouvi PVercelletto MFranconie CLenoir HLeclercq MDubois BDieudonnee BGibbons LBugnicourt JMVallat-Azouvi CKrier CRobert PRoussel MLe Gall DBioux SMarquet VPillon BMeulemans TMichel EGiroire JMDe Rotrou JSeron XLeys DGodefroy OFuchs JNyenhuis DBretault ECoyette FBlack SBernard IfalseValidation of an integrated method for determining cognitive ability: Implications for routine assessments and clinical trials.<h4>Introduction</h4>Although accurate diagnosis of deficit of mild intensity is critical, various methods are used to assess, dichotomize and integrate performance, with no validated gold standard. This study described and validated a framework for the analysis of cognitive performance.<h4>Methods</h4>This study was performed by using the Groupe de Réflexion sur L'Evaluation des Fonctions EXécutives (GREFEX) database (724 controls and 461 patients) examined by 7 tests assessing executive functions. The first phase determined the criteria for the cutoff scores, the second phase, the effect of test number on diagnostic accuracy and the third phase, the best methods for combining test scores into an overall summary score. Four validation criteria were used: determination of impaired performa2014-01-01T00:00:00Z2014 May2025-04-04T14:06:09.094Z2019-03-27T02:08:08ZS-EPMC47376502463246410.1016/j.cortex.2014.01.016