{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Li S"],"pubmed_abstract":["Benzoic acids are highly important structural motifs in drug molecules and natural products. Selective C-H bond functionalization of benzoic acids will provide synthetically useful tools for step-economical organic synthesis. Although direct ortho-C-H functionalizations of benzoic acids or their derivatives have been intensely studied, the ability to activate meta-C-H bond of benzoic acids or their derivatives in a general manner via transition-metal catalysis has been largely unsuccessful. Although chelation-assisted meta-C-H functionalization of electron-rich arenes was reported, chelation-assisted meta-C-H activation of electron-poor arenes such as benzoic acid derivatives remains a formidable challenge. Herein, we report a general protocol for meta-C-H olefination of benzoic acid deriv"],"journal":["Nature communications"],"pagination":["10443"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4737847"],"repository":["biostudies-literature"],"pubmed_title":["Pd(II)-catalysed meta-C-H functionalizations of benzoic acid derivatives."],"pmcid":["PMC4737847"],"pubmed_authors":["Li G","Li S","Ji H","Yang L","Cai L"],"additional_accession":[]},"is_claimable":false,"name":"Pd(II)-catalysed meta-C-H functionalizations of benzoic acid derivatives.","description":"Benzoic acids are highly important structural motifs in drug molecules and natural products. Selective C-H bond functionalization of benzoic acids will provide synthetically useful tools for step-economical organic synthesis. Although direct ortho-C-H functionalizations of benzoic acids or their derivatives have been intensely studied, the ability to activate meta-C-H bond of benzoic acids or their derivatives in a general manner via transition-metal catalysis has been largely unsuccessful. Although chelation-assisted meta-C-H functionalization of electron-rich arenes was reported, chelation-assisted meta-C-H activation of electron-poor arenes such as benzoic acid derivatives remains a formidable challenge. Herein, we report a general protocol for meta-C-H olefination of benzoic acid deriv","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-04T14:06:21.811Z","creation":"2019-03-27T02:08:10Z"},"accession":"S-EPMC4737847","cross_references":{"pubmed":["26813919"],"doi":["10.1038/ncomms10443"]}}