biostudies-literatureUnknown7Li SBenzoic acids are highly important structural motifs in drug molecules and natural products. Selective C-H bond functionalization of benzoic acids will provide synthetically useful tools for step-economical organic synthesis. Although direct ortho-C-H functionalizations of benzoic acids or their derivatives have been intensely studied, the ability to activate meta-C-H bond of benzoic acids or their derivatives in a general manner via transition-metal catalysis has been largely unsuccessful. Although chelation-assisted meta-C-H functionalization of electron-rich arenes was reported, chelation-assisted meta-C-H activation of electron-poor arenes such as benzoic acid derivatives remains a formidable challenge. Herein, we report a general protocol for meta-C-H olefination of benzoic acid derivNature communications10443https://www.ebi.ac.uk/biostudies/studies/S-EPMC4737847biostudies-literaturePd(II)-catalysed meta-C-H functionalizations of benzoic acid derivatives.PMC4737847Li GLi SJi HYang LCai LfalsePd(II)-catalysed meta-C-H functionalizations of benzoic acid derivatives.Benzoic acids are highly important structural motifs in drug molecules and natural products. Selective C-H bond functionalization of benzoic acids will provide synthetically useful tools for step-economical organic synthesis. Although direct ortho-C-H functionalizations of benzoic acids or their derivatives have been intensely studied, the ability to activate meta-C-H bond of benzoic acids or their derivatives in a general manner via transition-metal catalysis has been largely unsuccessful. Although chelation-assisted meta-C-H functionalization of electron-rich arenes was reported, chelation-assisted meta-C-H activation of electron-poor arenes such as benzoic acid derivatives remains a formidable challenge. Herein, we report a general protocol for meta-C-H olefination of benzoic acid deriv2016-01-01T00:00:00Z2016 Jan2025-04-04T14:06:21.811Z2019-03-27T02:08:10ZS-EPMC47378472681391910.1038/ncomms10443