{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Symonds EL"],"pubmed_abstract":["<h4>Objectives</h4>To compare the performance of a new blood test for colorectal cancer (CRC) to an established fecal immunochemical test (FIT) in a study population with the full range of neoplastic and non-neoplastic pathologies encountered in the colon and rectum.<h4>Methods</h4>Volunteers were asked to complete a FIT prior to colonoscopy. Blood was collected after bowel preparation but prior to colonoscopy, and plasma was assayed for the presence of methylated BCAT1 and IKZF1 DNA using a multiplex real-time PCR assay. Sensitivity and specificity estimates for the blood test were calculated from true- and false-positive rates for neoplasia and compared with FIT at a range of fecal hemoglobin (Hb) concentration positivity thresholds.<h4>Results</h4>In total, 1,381 volunteers (median age "],"journal":["Clinical and translational gastroenterology"],"pagination":["e137"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4737873"],"repository":["biostudies-literature"],"pubmed_title":["A Blood Test for Methylated BCAT1 and IKZF1 vs. a Fecal Immunochemical Test for Detection of Colorectal Neoplasia."],"pmcid":["PMC4737873"],"pubmed_authors":["Pedersen SK","Cole SR","Young GP","Symonds EL","Gopalsamy G","Murray DH","Mangira D","Baker RT","Gaur S","LaPointe LC"],"additional_accession":[]},"is_claimable":false,"name":"A Blood Test for Methylated BCAT1 and IKZF1 vs. a Fecal Immunochemical Test for Detection of Colorectal Neoplasia.","description":"<h4>Objectives</h4>To compare the performance of a new blood test for colorectal cancer (CRC) to an established fecal immunochemical test (FIT) in a study population with the full range of neoplastic and non-neoplastic pathologies encountered in the colon and rectum.<h4>Methods</h4>Volunteers were asked to complete a FIT prior to colonoscopy. Blood was collected after bowel preparation but prior to colonoscopy, and plasma was assayed for the presence of methylated BCAT1 and IKZF1 DNA using a multiplex real-time PCR assay. Sensitivity and specificity estimates for the blood test were calculated from true- and false-positive rates for neoplasia and compared with FIT at a range of fecal hemoglobin (Hb) concentration positivity thresholds.<h4>Results</h4>In total, 1,381 volunteers (median age ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-04T14:06:25.846Z","creation":"2019-03-27T02:08:09Z"},"accession":"S-EPMC4737873","cross_references":{"pubmed":["26765125"],"doi":["10.1038/ctg.2015.67"]}}