biostudies-literatureImamura MBritish Heart FoundationEuropean Research CouncilNIDDK NIH HHSNCRR NIH HHSFIC NIH HHSMedical Research CouncilNCI NIH HHSNNF Center for Basic Metabolic ResearchWellcome Trust10531https://www.ebi.ac.uk/biostudies/studies/S-EPMC4738362biostudies-literatureUnknown7Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.Nature communicationsGenome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.PMC4738362K01 TW006087268834UM1 CA182910KO1TW006087R37CA070867279233SP/09/002R37 CA070867R01 CA064277R01CA124558R01 CA124558Grarup GroupR01CA64277G0800270UL1 RR024975BC050791R01 DK082766R01DK082766Florez JCBurtt NPHirose HWatada HTai ESZhang RKaku KYasuda KWang XJorgensen MEIto CHosoe JMoon SMaeda STakahashi AKawamori RHuerta-Chagoya ASanghera DZheng WKim BJSingh JRCho YSHu CMaegawa HChristensen CMercader JMShojima NLong JSaxena RZhao WKadowaki TSuzuki KPark KSTanaka YDanesh JKim YJHara KJia WIwasaki MKubo MRasheed AYamauchi TBrandslund ITam CHChan JCPedersen OFrossard PShu XOImamura MTobe KIwata MFujita HWitte DRTusie-Luna THansen TMoreno-Macias HKwak SHOkada YMa RCGrarup NJorgensen TSaleheen DFlannick JfalseGenome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.2016-01-01T00:00:00Z2016 Jan2024-11-08T14:59:48.167Z2019-03-27T02:08:14ZS-EPMC47383622681894710.1038/ncomms10531