{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vieira GC"],"funding":["Cancer Research UK"],"pagination":["40053-67"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4741879"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(37)"],"pubmed_abstract":["LGR5 is a marker of normal and cancer stem cells in various tissues where it functions as a receptor for R-spondins and increases canonical Wnt signalling amplitude. Here we report that LGR5 is also highly expressed in a subset of high grade neuroblastomas. Neuroblastoma is a clinically heterogenous paediatric cancer comprising a high proportion of poor prognosis cases (~40%) which are frequently lethal. Unlike many cancers, Wnt pathway mutations are not apparent in neuroblastoma, although previous microarray analyses have implicated deregulated Wnt signalling in high-risk neuroblastoma. We demonstrate that LGR5 facilitates high Wnt signalling in neuroblastoma cell lines treated with Wnt3a and R-spondins, with SK-N-BE(2)-C, SK-N-NAS and SH-SY5Y cell-lines all displaying strong Wnt inductio"],"journal":["Oncotarget"],"pubmed_title":["LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma."],"pmcid":["PMC4741879"],"funding_grant_id":["C20791/A12743","11975","12743"],"pubmed_authors":["Zhou L","Catchpoole D","Malik S","Park JH","Greenhough A","Szemes M","Bates DO","Gabb PD","Kaidi A","Malik K","Melegh Z","Morgan R","Vieira GC","Chockalingam S"],"additional_accession":[]},"is_claimable":false,"name":"LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma.","description":"LGR5 is a marker of normal and cancer stem cells in various tissues where it functions as a receptor for R-spondins and increases canonical Wnt signalling amplitude. Here we report that LGR5 is also highly expressed in a subset of high grade neuroblastomas. Neuroblastoma is a clinically heterogenous paediatric cancer comprising a high proportion of poor prognosis cases (~40%) which are frequently lethal. Unlike many cancers, Wnt pathway mutations are not apparent in neuroblastoma, although previous microarray analyses have implicated deregulated Wnt signalling in high-risk neuroblastoma. We demonstrate that LGR5 facilitates high Wnt signalling in neuroblastoma cell lines treated with Wnt3a and R-spondins, with SK-N-BE(2)-C, SK-N-NAS and SH-SY5Y cell-lines all displaying strong Wnt inductio","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Nov","modification":"2026-05-05T12:00:52.053Z","creation":"2026-04-07T21:44:05.349Z"},"accession":"S-EPMC4741879","cross_references":{"pubmed":["26517508"],"doi":["10.18632/oncotarget.5548"]}}