biostudies-literatureSilva-Alvarez VComisión Sectorial de Investigación Científica (UY)69https://www.ebi.ac.uk/biostudies/studies/S-EPMC4743400biostudies-literatureUnknown9<h4>Background</h4>Antigen B (EgAgB) is an abundant lipoprotein released by the larva of the cestode Echinococcus granulosus into the host tissues. Its protein moiety belongs to the cestode-specific family known as hydrophobic ligand binding protein (HLBP), and is encoded by five gene subfamilies (EgAgB8/1-EgAgB8/5). The functions of EgAgB in parasite biology remain unclear. It may play a role in the parasite's lipid metabolism since it carries host lipids that E. granulosus is unable to synthesise. On the other hand, there is evidence supporting immuno-modulating activities in EgAgB, particularly on innate immune cells. Both hypothetical functions might involve EgAgB interactions with monocytes and macrophages, which have not been formally analysed yet.<h4>Methods</h4>EgAgB binding to monParasites & vectorsEchinococcus granulosus Antigen B binds to monocytes and macrophages modulating cell response to inflammation.PMC4743400Programa I+D Grupos, Grant 977 (2015-2018)Folle AMKitano ESSilva-Alvarez VRamos ALIwai LKCorraliza IFerreira AMCorsico BfalseEchinococcus granulosus Antigen B binds to monocytes and macrophages modulating cell response to inflammation.<h4>Background</h4>Antigen B (EgAgB) is an abundant lipoprotein released by the larva of the cestode Echinococcus granulosus into the host tissues. Its protein moiety belongs to the cestode-specific family known as hydrophobic ligand binding protein (HLBP), and is encoded by five gene subfamilies (EgAgB8/1-EgAgB8/5). The functions of EgAgB in parasite biology remain unclear. It may play a role in the parasite's lipid metabolism since it carries host lipids that E. granulosus is unable to synthesise. On the other hand, there is evidence supporting immuno-modulating activities in EgAgB, particularly on innate immune cells. Both hypothetical functions might involve EgAgB interactions with monocytes and macrophages, which have not been formally analysed yet.<h4>Methods</h4>EgAgB binding to mon2016-01-01T00:00:00Z2016 Feb2026-06-10T03:21:41.081Z2019-03-27T02:08:34ZS-EPMC47434002684670010.1186/s13071-016-1350-7