{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hishimoto A"],"funding":["NCRR NIH HHS","NIDA NIH HHS","NCI NIH HHS","NIH","Albert Einstein College of Medicine"],"pagination":["415-420"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4744103"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(5)"],"pubmed_abstract":["Matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS) (MALDI-IMS) provides a technical means for simultaneous analysis of precise anatomic localization and regulation of peptides. We explored the technical capability of matrix-assisted laser desorption ionization mass spectrometry for characterization of peptidomic regulation by an addictive substance along two distinct projection systems in the mouse striatum. The spatial expression patterns of substance P and proenkephalin, marker neuropeptides of two distinct striatal projection neurons, were negatively correlated at baseline. We detected 768 mass/charge (m/z) peaks whose expression levels were mostly negatively and positively correlated with expression levels of substance P and proenkephalin A (amino acids"],"journal":["Biological psychiatry"],"pubmed_title":["Molecular Histochemistry Identifies Peptidomic Organization and Reorganization Along Striatal Projection Units."],"pmcid":["PMC4744103"],"funding_grant_id":["S10 RR025128","1S10RR029398","P30 CA013330","R01 DA024330","R01DA024330","S10 RR029398","1S10RR025128"],"pubmed_authors":["Aguilan JT","Nishi A","Kang G","Angeletti RH","Lim J","Hishimoto A","Nomaru H","Ye K","Nieves E","Hiroi N"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Histochemistry Identifies Peptidomic Organization and Reorganization Along Striatal Projection Units.","description":"Matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS) (MALDI-IMS) provides a technical means for simultaneous analysis of precise anatomic localization and regulation of peptides. We explored the technical capability of matrix-assisted laser desorption ionization mass spectrometry for characterization of peptidomic regulation by an addictive substance along two distinct projection systems in the mouse striatum. The spatial expression patterns of substance P and proenkephalin, marker neuropeptides of two distinct striatal projection neurons, were negatively correlated at baseline. We detected 768 mass/charge (m/z) peaks whose expression levels were mostly negatively and positively correlated with expression levels of substance P and proenkephalin A (amino acids","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Mar","modification":"2025-04-21T19:26:20.703Z","creation":"2019-03-27T02:08:36Z"},"accession":"S-EPMC4744103","cross_references":{"pubmed":["26520239"],"doi":["10.1016/j.biopsych.2015.09.012"]}}