{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(30)"],"submitter":["Pires ES"],"pubmed_abstract":["The metalloproteinase SAS1B [ovastacin, ASTL, astacin-like] was immunolocalized on the oolemma of ovulated human oocytes and in normal ovaries within the pool of growing oocytes where SAS1B protein was restricted to follicular stages spanning the primary-secondary follicle transition through ovulation. Gene-specific PCR and immunohistochemical studies revealed ASTL messages and SAS1B protein in both endometrioid [74%] and malignant mixed Mullerian tumors (MMMT) [87%] of the uterus. A MMMT-derived cell line, SNU539, expressed cell surface SAS1B that, after binding polyclonal antibodies, internalized into EEA1/LAMP1-positive early and late endosomes. Treatment of SNU539 cells with anti-SAS1B polyclonal antibodies caused growth arrest in the presence of active complement. A saporin-immunotoxi"],"journal":["Oncotarget"],"pagination":["30194-211"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4745790"],"repository":["biostudies-literature"],"pubmed_title":["Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors."],"pmcid":["PMC4745790"],"pubmed_authors":["Flickinger CJ","Li H","Jazaeri AA","Herr JC","Bruns DE","D'Souza RS","Stoler MH","Mandal A","Needham MA","Anderson-Knapp KL","Gougeon A","Herr AK","Thomas T","Pollok BA","Pires ES"],"additional_accession":[]},"is_claimable":false,"name":"Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors.","description":"The metalloproteinase SAS1B [ovastacin, ASTL, astacin-like] was immunolocalized on the oolemma of ovulated human oocytes and in normal ovaries within the pool of growing oocytes where SAS1B protein was restricted to follicular stages spanning the primary-secondary follicle transition through ovulation. Gene-specific PCR and immunohistochemical studies revealed ASTL messages and SAS1B protein in both endometrioid [74%] and malignant mixed Mullerian tumors (MMMT) [87%] of the uterus. A MMMT-derived cell line, SNU539, expressed cell surface SAS1B that, after binding polyclonal antibodies, internalized into EEA1/LAMP1-positive early and late endosomes. Treatment of SNU539 cells with anti-SAS1B polyclonal antibodies caused growth arrest in the presence of active complement. A saporin-immunotoxi","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Oct","modification":"2026-05-05T20:26:08.573Z","creation":"2019-03-27T02:08:41Z"},"accession":"S-EPMC4745790","cross_references":{"pubmed":["26327203"],"doi":["10.18632/oncotarget.4734"]}}