{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Campana R"],"funding":["Austrian Science Fund FWF"],"pagination":["601-609.e8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4748398"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["137(2)"],"pubmed_abstract":["<h4>Background</h4>Late allergic reactions are common in the course of allergen-specific immunotherapy and even occur with allergy vaccines with reduced IgE reactivity.<h4>Objective</h4>We sought to study atopy patch test (APT) reactions and T-cell responses to the recombinant birch pollen allergen Bet v 1 and recombinant hypoallergenic T-cell epitope-containing Bet v 1 fragments in patients with birch pollen allergy with and without atopic dermatitis (AD).<h4>Methods</h4>A clinical study was conducted in 15 patients with birch pollen allergy with AD (group 1), 5 patients with birch pollen allergy without AD (group 2), 5 allergic patients without birch pollen allergy (group 3), and 5 nonallergic subjects (group 4) by performing skin prick tests and APTs with rBet v 1 and hypoallergenic rBe"],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["Frequent occurrence of T cell-mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments."],"pmcid":["PMC4748398"],"funding_grant_id":["F 4605"],"pubmed_authors":["Brodie TM","Sallusto F","Henning R","Valenta R","Wohrl S","Kaider A","Campana R","Neubauer A","Hoermann G","Valent P","Huber H","Blatt K","Moritz K","Marth K"],"additional_accession":[]},"is_claimable":false,"name":"Frequent occurrence of T cell-mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments.","description":"<h4>Background</h4>Late allergic reactions are common in the course of allergen-specific immunotherapy and even occur with allergy vaccines with reduced IgE reactivity.<h4>Objective</h4>We sought to study atopy patch test (APT) reactions and T-cell responses to the recombinant birch pollen allergen Bet v 1 and recombinant hypoallergenic T-cell epitope-containing Bet v 1 fragments in patients with birch pollen allergy with and without atopic dermatitis (AD).<h4>Methods</h4>A clinical study was conducted in 15 patients with birch pollen allergy with AD (group 1), 5 patients with birch pollen allergy without AD (group 2), 5 allergic patients without birch pollen allergy (group 3), and 5 nonallergic subjects (group 4) by performing skin prick tests and APTs with rBet v 1 and hypoallergenic rBe","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Feb","modification":"2026-05-04T08:16:48.55Z","creation":"2019-03-27T02:08:50Z"},"accession":"S-EPMC4748398","cross_references":{"pubmed":["26518092"],"doi":["10.1016/j.jaci.2015.08.042"]}}