biostudies-literatureCampana RAustrian Science Fund FWF601-609.e8https://www.ebi.ac.uk/biostudies/studies/S-EPMC4748398biostudies-literatureUnknown137(2)<h4>Background</h4>Late allergic reactions are common in the course of allergen-specific immunotherapy and even occur with allergy vaccines with reduced IgE reactivity.<h4>Objective</h4>We sought to study atopy patch test (APT) reactions and T-cell responses to the recombinant birch pollen allergen Bet v 1 and recombinant hypoallergenic T-cell epitope-containing Bet v 1 fragments in patients with birch pollen allergy with and without atopic dermatitis (AD).<h4>Methods</h4>A clinical study was conducted in 15 patients with birch pollen allergy with AD (group 1), 5 patients with birch pollen allergy without AD (group 2), 5 allergic patients without birch pollen allergy (group 3), and 5 nonallergic subjects (group 4) by performing skin prick tests and APTs with rBet v 1 and hypoallergenic rBeThe Journal of allergy and clinical immunologyFrequent occurrence of T cell-mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments.PMC4748398F 4605Brodie TMSallusto FHenning RValenta RWohrl SKaider ACampana RNeubauer AHoermann GValent PHuber HBlatt KMoritz KMarth KfalseFrequent occurrence of T cell-mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments.<h4>Background</h4>Late allergic reactions are common in the course of allergen-specific immunotherapy and even occur with allergy vaccines with reduced IgE reactivity.<h4>Objective</h4>We sought to study atopy patch test (APT) reactions and T-cell responses to the recombinant birch pollen allergen Bet v 1 and recombinant hypoallergenic T-cell epitope-containing Bet v 1 fragments in patients with birch pollen allergy with and without atopic dermatitis (AD).<h4>Methods</h4>A clinical study was conducted in 15 patients with birch pollen allergy with AD (group 1), 5 patients with birch pollen allergy without AD (group 2), 5 allergic patients without birch pollen allergy (group 3), and 5 nonallergic subjects (group 4) by performing skin prick tests and APTs with rBet v 1 and hypoallergenic rBe2016-01-01T00:00:00Z2016 Feb2026-05-04T08:16:48.55Z2019-03-27T02:08:50ZS-EPMC47483982651809210.1016/j.jaci.2015.08.042