{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Winerdal M"],"pubmed_abstract":["Neonatal brain hypoxic ischemia (HI) often results in long-term motor and cognitive impairments. Post-ischemic inflammation greatly effects outcome and adenosine receptor signaling modulates both HI and immune cell function. Here, we investigated the influence of adenosine A1 receptor deficiency (A1R(-/-)) on key immune cell populations in a neonatal brain HI model. Ten-day-old mice were subjected to HI. Functional outcome was assessed by open locomotion and beam walking test and infarction size evaluated. Flow cytometry was performed on brain-infiltrating cells, and semi-automated analysis of flow cytometric data was applied. A1R(-/-) mice displayed larger infarctions (+33%, p < 0.05) and performed worse in beam walking tests (44% more mistakes, p < 0.05) than wild-type (WT) mice. Myeloid"],"journal":["Purinergic signalling"],"pagination":["89-101"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4749537"],"repository":["biostudies-literature"],"pubmed_title":["Adenosine A1 receptors contribute to immune regulation after neonatal hypoxic ischemic brain injury."],"pmcid":["PMC4749537"],"pubmed_authors":["Wang YQ","Fredholm BB","Winerdal M","Winerdal ME","Winqvist O","Aden U"],"additional_accession":[]},"is_claimable":false,"name":"Adenosine A1 receptors contribute to immune regulation after neonatal hypoxic ischemic brain injury.","description":"Neonatal brain hypoxic ischemia (HI) often results in long-term motor and cognitive impairments. Post-ischemic inflammation greatly effects outcome and adenosine receptor signaling modulates both HI and immune cell function. Here, we investigated the influence of adenosine A1 receptor deficiency (A1R(-/-)) on key immune cell populations in a neonatal brain HI model. Ten-day-old mice were subjected to HI. Functional outcome was assessed by open locomotion and beam walking test and infarction size evaluated. Flow cytometry was performed on brain-infiltrating cells, and semi-automated analysis of flow cytometric data was applied. A1R(-/-) mice displayed larger infarctions (+33%, p < 0.05) and performed worse in beam walking tests (44% more mistakes, p < 0.05) than wild-type (WT) mice. Myeloid","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Mar","modification":"2026-05-05T08:33:40.866Z","creation":"2019-03-27T02:08:56Z"},"accession":"S-EPMC4749537","cross_references":{"pubmed":["26608888"],"doi":["10.1007/s11302-015-9482-3"]}}