{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Balasubramanian K"],"funding":["BLRD VA","Human Frontier Science Program","NIEHS NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NIOSH CDC HHS","UPCI Cancer Biomarkers Facility/Luminex Core Laboratory","NCI NIH HHS","NINDS NIH HHS","Swedish Research Council","NIH","PHS HHS"],"pagination":["ra95"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4760701"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(395)"],"pubmed_abstract":["Among the distinct molecular signatures present in the mitochondrion is the tetra-acylated anionic phospholipid cardiolipin, a lipid also present in primordial, single-cell bacterial ancestors of mitochondria and multiple bacterial species today. Cardiolipin is normally localized to the inner mitochondrial membrane; however, when cardiolipin becomes externalized to the surface of dysregulated mitochondria, it promotes inflammasome activation and stimulates the elimination of damaged or nonfunctional mitochondria by mitophagy. Given the immunogenicity of mitochondrial and bacterial membranes that are released during sterile and pathogen-induced trauma, we hypothesized that cardiolipins might function as \"eat me\" signals for professional phagocytes. In experiments with macrophage cell lines "],"journal":["Science signaling"],"pubmed_title":["Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity."],"pmcid":["PMC4760701"],"funding_grant_id":["P30CA047904","R01 ES020693","ES020693","NIOSH OH008282","R37 NS061817","U19AIO68021","CA165065","HL086884","I01 BX002200","U19 AI068021","UH2 HL123502","PO1 HL114453","R01 NS061817","R01 HL086884","NS061817","NS076511","P01 HL114453","OH008282","R01 HL098174","R01 HL096376","P30 CA047904","R01 CA165065","R01 HL081784","R01 OH008282","R01 NS076511","HFSP-RGP0013/2014"],"pubmed_authors":["St Croix CM","Mohammadyani D","Kloditz K","Klein-Seetharaman J","Jiang JF","Polimova A","Kapralova VI","Maeda A","Ray P","Mallampalli RK","Balasubramanian K","Tyurina YY","Lee JS","Bayir H","Kagan VE","Xiong Z","Fadeel B","Watkins S","Tyurin VA","Dar HH"],"additional_accession":[]},"is_claimable":false,"name":"Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity.","description":"Among the distinct molecular signatures present in the mitochondrion is the tetra-acylated anionic phospholipid cardiolipin, a lipid also present in primordial, single-cell bacterial ancestors of mitochondria and multiple bacterial species today. Cardiolipin is normally localized to the inner mitochondrial membrane; however, when cardiolipin becomes externalized to the surface of dysregulated mitochondria, it promotes inflammasome activation and stimulates the elimination of damaged or nonfunctional mitochondria by mitophagy. Given the immunogenicity of mitochondrial and bacterial membranes that are released during sterile and pathogen-induced trauma, we hypothesized that cardiolipins might function as \"eat me\" signals for professional phagocytes. In experiments with macrophage cell lines ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2026-05-05T06:40:42.724Z","creation":"2019-03-27T02:09:29Z"},"accession":"S-EPMC4760701","cross_references":{"pubmed":["26396268"],"doi":["10.1126/scisignal.aaa6179"]}}