{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng Y"],"funding":["National Institutes of Health","NIGMS NIH HHS"],"pagination":["6510-6514"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4762611"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(11)"],"pubmed_abstract":["An unprecedented highly diastereoselective and enantioselective aldol reaction of α-alkyl azlactones and aliphatic aldehydes was achieved with cinchona alkaloid catalysts. To our knowledge, this reaction provides the first useful catalytic asymmetric access toward β-hydroxy-α-amino acids bearing alkyl substituents, which are structural motifs embedded in many natural products."],"journal":["Chemical science"],"pubmed_title":["Catalytic Asymmetric Direct Aldol Reaction of α-Alkyl Azlactones and Aliphatic Aldehydes."],"pmcid":["PMC4762611"],"funding_grant_id":["R01 GM061591","GM-61591"],"pubmed_authors":["Zheng Y","Deng L"],"additional_accession":[]},"is_claimable":false,"name":"Catalytic Asymmetric Direct Aldol Reaction of α-Alkyl Azlactones and Aliphatic Aldehydes.","description":"An unprecedented highly diastereoselective and enantioselective aldol reaction of α-alkyl azlactones and aliphatic aldehydes was achieved with cinchona alkaloid catalysts. To our knowledge, this reaction provides the first useful catalytic asymmetric access toward β-hydroxy-α-amino acids bearing alkyl substituents, which are structural motifs embedded in many natural products.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Nov","modification":"2026-05-05T16:44:35.099Z","creation":"2019-03-26T23:49:36Z"},"accession":"S-EPMC4762611","cross_references":{"pubmed":["26918108"],"doi":["10.1039/C5SC02116B"]}}